Abstract: PO1765
Relation Between Waist Circumference and Renal Hemodynamic in Healthy Individuals
Session Information
- Hypertension and CVD: New insights
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
Authors
- Bosch, Agnes, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Kannenkeril, Dennis, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Ott, Christian, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Pietschner, Robert, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Striepe, Kristina, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Schiffer, Mario, Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
- Schmieder, Roland E., Department of Nephrology and Hypertension, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Erlangen, Germany
Background
Abdominal adiposity, measured by waist circumference (WC), is associated with increased mortality in individuals with chronic kidney disease. Little is known about the impact of abdominal obesity on the renal perfusion and function in humans. We analyzed whether abdominal adiposity changes renal hemodynamics in 80 healthy, young, male individuals without cardiovascular (CV) disease.
Methods
We analysed the renal hemodynamic using steady state input clearance with infusion of paraaminohippuric acid and inulin, respectively. Intraglomerular pressure and resistances of the afferent (RA) and efferent (RE) arterioles were calculated according to the Gomez equation. The study population was divided in into two groups based on median of WC of the total study population.
Results
The study cohort consisted of male, non-smoking individuals, aged 27 ± 9 years. Mean of WC in the total study cohort was 84.75 ± 9 cm and just 9 patients showed WC > 94 cm (threshold for CV risk according to 2018 hypertension guidelines). Table 1 shows the renal hemodynamic in patients related to mean WC of the total study population. After adjustment for age and mean arterial blood pressure (MAP) using multivariate regression analysis the difference between both WC groups remained significant for the following parameters: RPF (p = 0.006), GFR (p = 0.017), RBF (p = 0.006), RVR (p = 0.006), IP (p = 0.018), RA (p = 0.005).
Conclusion
Increased WC in healthy young, male individuals without cardiovascular disease was associated with reduced GFR and reduced RPF. This effect is likely to be mediated by increased renal vascular resistance, more precisely vasoconstriction of the renal vas afferens.
| Renal parameters | Waist circumference (WC) | Waist circumference (WC) / body height | ||||
| ≥ median | < median | p-value | ≥ median | < median | p-value | |
| Renal plasma flow (ml/min) | 620 ± 109 | 700 ± 104 | 0.001 | 630 ± 115 | 693 ± 103 | 0.011 |
| Glomerular filtration rate (ml/min) | 131 ± 11 | 140 ± 15 | 0.003 | 132 ± 12 | 140 ± 15 | 0.013 |
| Filtration fraction (-) | 22 ± 2.6 | 20 ± 2.1 | 0.017 | 21 ± 2.7 | 20 ± 1.9 | 0.054 |
| Renal blood flow (ml/min) | 1096 ± 193 | 1245 ± 197 | 0.001 | 1115 ± 207 | 1231 ± 193 | 0.013 |
| Renal vascular resistance (mmHg/(ml/min)) | 85 ± 19 | 70 ± 12 | < 0.001 | 83 ± 19 | 71 ± 13 | 0.001 |
| Intraglomerular pressure (mmHg) | 36.7 ± 2.3 | 38.5 ± 3.1 | 0.003 | 36.8 ± 2.5 | 38.4 ± 3.1 | 0.014 |
| Resistance vas afferens (dyn*s/cm5) | 4034 ± 1177 | 3069 ± 786 | < 0.001 | 3953 ± 1164 | 3106 ± 852 | < 0.001 |
| Resistance vas efferens (dyn*s/cm5) | 2283 ± 339 | 2118 ± 280 | 0.021 | 2263 ± 361 | 2131 ± 254 | 0.062 |
Table 1: Data are presented as mean ± SD