Abstract: PO2390
Serum Creatinine Concentration and Estimates of Muscle Mass Among Race/Ethnicity Groups with End-Stage Kidney Failure
Session Information
- CKD: Insights from Recent Clinical Trials and Large Real-World Effectiveness Studies
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Delgado, Cynthia, San Francisco VA Health Care System, San Francisco, California, United States
- Powe, Neil R., Zuckerberg San Francisco General Hospital and Trauma Center, San Francisco, California, United States
- Chertow, Glenn Matthew, Stanford University School of Medicine, Stanford, California, United States
- Grimes, Barbara A., University of California San Francisco, San Francisco, California, United States
- Johansen, Kirsten L., Hennepin Healthcare, Minneapolis, Minnesota, United States
Background
Racial differences in serum creatinine concentration have been attributed to differences in muscle mass. We examined this hypothesis among End Stage Kidney Disease patients receiving hemodialysis, whose serum creatinine concentration (SCr) should not be highly influenced by glomerular filtration.
Methods
501 participants were enrolled from 2 centers who were at least 1 year post start of hemodialysis and for whom we measured SCr and body composition (including height-adjusted intracellular water [ICW] as a surrogate of muscle mass) using bioelectrical impedance spectroscopy. In multivariable linear regression we examined the independent association of race/ethnicity (Black, Asian, Non-Hispanic White (NHW), and Hispanic) with estimated muscle mass. We then examined whether race/ethnicity was associated with SCr with adjustment for demographics, clinical factors and body composition including ICW.
Results
Black (0.24 (-0.01,0.49)) and Hispanic (0.05 (-0.26, 0.37)) participants had similar ICW to that of NHW, but ICW was higher among Asians (0.42 (0.11, 0.72)). In contrast, SCr concentrations were significantly higher among Blacks, Hispanics and Asians compared with NHW. Adjustment for ICW did not change these associations or attenuate the difference in SCr between any racial/ethnic group and NHWs.
Conclusion
Among prevalent dialysis participants, ICW, a muscle mass surrogate, was higher among Asian, but not among Black, participants when compared to NHW. After adjusting for ICW, higher SCr was observed across all race ethnicity categories and muscle mass did not appear to explain differences in SCr by race/ethnicity.
Funding
- NIDDK Support