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Kidney Week

Abstract: PO2147

Development Following Paediatric Kidney Transplantation

Session Information

Category: Transplantation

  • 1902 Transplantation: Clinical

Authors

  • Pape, Lars, Universitat Duisburg-Essen, Essen, Nordrhein-Westfalen, Germany
  • Pruefe, Jenny, Universitat Duisburg-Essen, Essen, Nordrhein-Westfalen, Germany
Background

This study aims to assess quality of life, mental health, motor development, executive functioning and medication adherence in paediatric patients following kidney transplantation

Methods

In a cross-sectional study we used standardised tools (FABEL, KINDL, PedsQL, CBCL, M-ABC, WISC-V, BAASIS) to assess the relevant parameters and analyse them against the background of selected medical data.

Results

We included 53 kidney transplanted children age 0-18 (♂32 ♀21). Parents reported increased financial burden and fear of the future. Half of the patients showed some symptoms of mental distress. 13/40 (32.5%) patients fulfilled DSM-criteria for mental health problems. Most frequent symptoms linked to depression and anxiety. Participants who started renal replacement therapy in their first three years of life mainly expressed symptoms of the externalising spectrum.
Motor-development could be assessed in 47 patients. Developmental deficits could manly be observed in the field of fine motor skills and dexterity as well as body-balance. In total 11/47 (23.4) patients had fine-motor-skills below the 2nd percentile, 14/47 (29.9%) had deficits in body-balance scoring below the 2nd percentile.
Processing speed was assessed in a subgroup of 36 patients without cognitive developmental delay. Mean score was 84 (45-112; sd 16.0). 5/36 (13.9%) patients had results below the 2nd percentile.

Conclusion

Even after successful transplantation chronic kidney disease seams to impact on the overall health and development of the affected child. While nowadays allograft survival is considered to be acceptable, it is time to shift focus on quality of survival and non-renal consequences of a renal disease. Besides further research clinical programs are needed to offer tailored assessments and support.