Abstract: SA-OR05
Immunological Response in Dialysis and Kidney Transplant Patients with SARS-CoV-2 Infection
Session Information
- COVID-19 and Kidney Diseases: From Bedside to Bench
November 06, 2021 | Location: Simulive, Virtual Only
Abstract Time: 04:30 PM - 06:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Affatato, Stefania, Universita degli Studi di Brescia, Brescia, Lombardia, Italy
- Mescia, Federica, Universita degli Studi di Brescia, Brescia, Lombardia, Italy
- Quaresima, Virginia, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Fiorini, Chiara, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Gaggiotti, Mario, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Bossini, Nicola, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Gaggia, Paola, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Badolato, Raffaele, Universita degli Studi di Brescia, Brescia, Lombardia, Italy
- Notarangelo, Luigi D., National Institute of Allergy and Infectious Diseases Laboratory of Clinical Immunology and Microbiology, Bethesda, Maryland, United States
- Chiarini, Marco, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, Brescia, Lombardia, Italy
- Scolari, Francesco, Universita degli Studi di Brescia, Brescia, Lombardia, Italy
- Alberici, Federico, Universita degli Studi di Brescia, Brescia, Lombardia, Italy
Background
Mortality for COVID-19 in dialysis(HD) and kidney transplant(TX) patients(pts) is 30%. In these pts the immunology of the disease has been poorly explored.
Methods
32 HD or TX pts hospitalized for COVID-19 (COV), of which 13 with benign course(PosCOV) and 19 who died or developed ARDS(NegCOV), 10 controls(HC) and 12 HD/TX without COVID-19(PC), have been included. Lymphocytes subsets, dendritic cells(DC) and monocytes activation (MA) have been explored.
Results
COV showed lower counts of CD4+, CD8+, CD56+, CD19+, DC and higher counts of terminally differentiated CD19+ compared to HC and PC; CD4+, CD8+, CD19+ and MA were significantly lower in NegCOV than PosCOV. Compared to HD, TX showed lower CD56+, pDC and MA.
Conclusion
The COV group showed immunological alterations compared to HC and PC with deeper alterations of the innate immune system in TX pts with COVID-19.
| Characteristics | PosCOV (13) | NegCOV (19) | p |
| Age (years; n - IQR) | 57 (48-73) | 73 (60-83) | 0.035 |
| Male/female (n) | 13/0 | 13/6 | 0.035 |
| HD/TX pt (n) | 5/8 | 12/7 | 0.280 |
| WBC (NV 4.00 – 10.80 x10^3/uL; μe - IQR) | 7.045 (4.35-7.61) | 6.240 (3.93-8.49) | 0.668 |
| Lymphocytes (NV 0.90 – 4.00 x10^3/uL; μe - IQR) | 0.74 (0.51-1.4) | 0.43 (0.36-1.02) | 0.026 |
| Neutrophils (NV 1.50 – 8.00 x10^3/uL; μe - IQR) | 5.04 (2.93-6.34) | 4.89 (3.06-7.75) | 0.451 |
| Monocytes (NV 0.2-1 x10^3/uL; μe - IQR) | 0.57 (0.50-0.67) | 0.41 (0.30-0.47) | 0.003 |