Abstract: PO1387
Targeting Sedentary Behavior in Older Adults: Subgroup Analysis of a Randomized Clinical Trial
Session Information
- Geriatric Nephrology: New Insights
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Geriatric Nephrology
- 1100 Geriatric Nephrology
Authors
- Abraham, Nikita, The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Boucher, Robert E., The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Wei, Guo, The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Christensen, Jesse, VA Salt Lake City Health Care System, Salt Lake City, Utah, United States
- Hartsell, Sydney Elizabeth, The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Carle, Judy, The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Gonce, Victoria, The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Supiano, Mark A., The University of Utah School of Medicine, Salt Lake City, Utah, United States
- Lyden, Kate, University of Massachusetts Amherst, Amherst, Massachusetts, United States
- Beddhu, Srinivasan, The University of Utah School of Medicine, Salt Lake City, Utah, United States
Background
Sedentary behavior (spending most of the awake hours in sitting/lying posture) is associated with increased mortality in CKD but few studies have examined the feasibility of interventions targeting sedentary behavior in older adults with CKD.
Methods
The Sit Less, Interact, Move More (SLIMM) Study was a 24-week RCT of an intervention to reduce sedenary duration with stepping duration in participants with CKD. Physical activity was measured using a mid-thigh accelerometer worn for 7 days before baseline and q4 weeks in standard of care (SOC) group (N=52) and baseline and q8 weeks in SLIMM group (N=54) . Based on the accelerometry data, SLIMM group was provided instructions on reducing sedentary duration. In this post-hoc analyses, we used mixed effect models to compare the effects of the SLIMM intervention in participants age ≥ 70 (N =59) versus age < 70 (N=47).
Results
Age ≥ 70 group compared to age < 70 group had a higher % of Whites and lower % of stage3b-5 CKD (Table 1). While sedentary duration was similar, the older group had lower stepping duration, gait speed and 6-min walk distance (Table 1). In mixed models, there were no significant differences between SLIMM and SOC groups for sedentary (1, 95% CI -39 to 42 min/d) and stepping (-4, 95% CI -18 to 11 min/d) durations and the number of steps/day (-424, 95% CI -1669 to 820) in the age < 70 group. The corresponding numbers for the age ≥ 70 group for sedentary and stepping durations and the number of steps/d were -28, (95% CI -61 to 5 min/d), 13, (95% CI 1 to 24 min/d) and 1330, (95% CI 322 to 2338 min/d), respectively.
Conclusion
It is feasible to decrease sedenaray behavior In older adults with CKD.
Baseline characteristics between age group
| Age>70 N=47 | Age≥70 N=59 | p-value | |
| Age,yrs | 58±11 | 78±5 | |
| Female,% | 30 | 53 | 0.019 |
| White,% | 79 | 98 | 0.001 |
| CKD Stages,% | 0.019 | ||
| Stage 2/3a | 43 | 42 | |
| Stage 3b | 26 | 46 | |
| Stage 4/5 | 32 | 12 | |
| Sedentary duration, min/d | 641±151 | 653±107 | 0.62 |
| Stepping duration, min/d | 98±61 | 75±26 | 0.01 |
| Steps/d | 6228 (3146,8446) | 4910 (4026,6470) | 0.26 |
Funding
- NIDDK Support