Abstract: PO2372
Association Between Dietary Potassium Intake and Abdominal Aortic Calcification in US Adults
Session Information
- CKD: Insights from Recent Clinical Trials and Large Real-World Effectiveness Studies
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Xie, Yuping, Children's Hospital at Montefiore, Bronx, New York, United States
- Abramowitz, Matthew K., Albert Einstein College of Medicine, Bronx, New York, United States
- Chen, Wei, Albert Einstein College of Medicine, Bronx, New York, United States
Background
In ApoE-deficient mice, low dietary potassium intake promoted vascular calcification and high dietary potassium intake attenuated vascular calcification. We hypothesized high dietary potassium intake was associated with lower abdominal aortic calcification (AAC) among adults in the US.
Methods
Cross-sectional analyses were performed on 2535 participants from the National Health and Nutrition Examination Survey 2013-2014. Dietary potassium intake was obtained from two 24-h recall interviews and were categorized into quartiles (Q1:0.3-1.9, Q2: 2.0-2.4, Q3: 2.5-3.1 and Q4: 3.2-6.8 g/day). AAC was measured using dual-energy X-ray absorptiometry in adults over 40 years old and quantified using the Kauppila score system. AAC scores were categorized into: no AAC (AAC=0, reference group), mild/moderate (AAC>0-≤6) and severe AAC (AAC>6). Multinomial logistic regression was used to study the association between AAC and dietary potassium intake. Model was adjusted for demographics, hypertension, diabetes, smoking, eGFR, albuminuria, BMI, energy intake and physical activity.
Results
In the entire cohort, mean dietary potassium intake was 2.4±0.9 g/day; 21% had mild/moderate AAC and 9.4% had severe AAC. Dietary potassium intake was not associated with mild-moderate AAC (table). For severe AAC, dietary potassium intake was only associated with AAC when comparing dietary potassium in Q2 with Q1: Q2 was associated with lower odds of having severe AAC (OR 0.65 (95% CI: 0.46-0.92), p=0.02). This association remained significant in the fully adjusted model (OR 0.50 (95% CI: 0.29-0.86), p=0.02).
Conclusion
We found that higher dietary potassium intake was associated with lower odds of having severe AAC, but the association is only significant when comparing dietary potassium intake in Q2 with Q1. This nonlinear relationship between dietary potassium intake and AAC requires further investigations.
Multinomial logistic regression models of AAC with dietary potassium intake(g/day) in quartiles, N=2535
| Dietary potassium intake | Mild-moderate AAC versus no AAC | Severe AAC versus no AAC | ||
| Odds Ratio (95% CI) | P-value | Odds Ratio (95% CI) | P-value | |
| Q1 | Reference | Reference | ||
| Q2: Unadjusted Adjusted | 0.92 (0.54-1.56) 0.85 (0.48-1.50) | 0.74 0.56 | 0.65 (0.46-0.92) 0.50 (0.29-0.86) | 0.02 0.02 |
| Q3: Unadjusted Adjusted | 0.78 (0.49-1.26) 0.79 (0.51-1.23) | 0.29 0.27 | 0.99 (0.59-1.65) 0.92 (0.37-2.31) | 0.97 0.85 |
| Q4: Unadjusted Adjusted | 1.09 (0.65-1.82) 0.99 (0.56-1.72) | 0.73 0.95 | 0.57 (0.28-1.14) 0.41 (0.11-1.51) | 0.11 0.17 |
Funding
- NIDDK Support