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Abstract: PO2372

Association Between Dietary Potassium Intake and Abdominal Aortic Calcification in US Adults

Session Information

Category: CKD (Non-Dialysis)

  • 2102 CKD (Non-Dialysis): Clinical, Outcomes, and Trials

Authors

  • Xie, Yuping, Children's Hospital at Montefiore, Bronx, New York, United States
  • Abramowitz, Matthew K., Albert Einstein College of Medicine, Bronx, New York, United States
  • Chen, Wei, Albert Einstein College of Medicine, Bronx, New York, United States
Background

In ApoE-deficient mice, low dietary potassium intake promoted vascular calcification and high dietary potassium intake attenuated vascular calcification. We hypothesized high dietary potassium intake was associated with lower abdominal aortic calcification (AAC) among adults in the US.

Methods

Cross-sectional analyses were performed on 2535 participants from the National Health and Nutrition Examination Survey 2013-2014. Dietary potassium intake was obtained from two 24-h recall interviews and were categorized into quartiles (Q1:0.3-1.9, Q2: 2.0-2.4, Q3: 2.5-3.1 and Q4: 3.2-6.8 g/day). AAC was measured using dual-energy X-ray absorptiometry in adults over 40 years old and quantified using the Kauppila score system. AAC scores were categorized into: no AAC (AAC=0, reference group), mild/moderate (AAC>0-≤6) and severe AAC (AAC>6). Multinomial logistic regression was used to study the association between AAC and dietary potassium intake. Model was adjusted for demographics, hypertension, diabetes, smoking, eGFR, albuminuria, BMI, energy intake and physical activity.

Results

In the entire cohort, mean dietary potassium intake was 2.4±0.9 g/day; 21% had mild/moderate AAC and 9.4% had severe AAC. Dietary potassium intake was not associated with mild-moderate AAC (table). For severe AAC, dietary potassium intake was only associated with AAC when comparing dietary potassium in Q2 with Q1: Q2 was associated with lower odds of having severe AAC (OR 0.65 (95% CI: 0.46-0.92), p=0.02). This association remained significant in the fully adjusted model (OR 0.50 (95% CI: 0.29-0.86), p=0.02).

Conclusion

We found that higher dietary potassium intake was associated with lower odds of having severe AAC, but the association is only significant when comparing dietary potassium intake in Q2 with Q1. This nonlinear relationship between dietary potassium intake and AAC requires further investigations.

Multinomial logistic regression models of AAC with dietary potassium intake(g/day) in quartiles, N=2535
Dietary potassium intakeMild-moderate AAC versus no AACSevere AAC versus no AAC
Odds Ratio (95% CI)P-valueOdds Ratio (95% CI)P-value
Q1Reference Reference 
Q2: Unadjusted
Adjusted
0.92 (0.54-1.56)
0.85 (0.48-1.50)
0.74
0.56
0.65 (0.46-0.92)
0.50 (0.29-0.86)
0.02
0.02
Q3: Unadjusted
Adjusted
0.78 (0.49-1.26)
0.79 (0.51-1.23)
0.29
0.27
0.99 (0.59-1.65)
0.92 (0.37-2.31)
0.97
0.85
Q4: Unadjusted
Adjusted
1.09 (0.65-1.82)
0.99 (0.56-1.72)
0.73
0.95
0.57 (0.28-1.14)
0.41 (0.11-1.51)
0.11
0.17

Funding

  • NIDDK Support