Abstract: PO2074
Mortality, Graft Survival, and Cardiovascular Outcomes in Adult Kidney Transplant Recipients with Post-Transplant Anemia: An Updated Meta-Analysis
Session Information
- Transplantation: Clinical - Allocation, Evaluation, Prognosis, and Viral Onslaughts
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Mekraksakit, Poemlarp, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
- Leelaviwat, Natnicha, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
- Boonpheng, Boonphiphop, University of California Los Angeles David Geffen School of Medicine, Los Angeles, California, United States
- Cheungpasitporn, Wisit, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Pena, Camilo, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
- Del Rio-Pertuz, Gaspar, Texas Tech University Health Sciences Center, Lubbock, Texas, United States
- Saxena, Ramesh, The University of Texas Southwestern Medical Center, Dallas, Texas, United States
Background
Post-transplant anemia (PTA) is a common finding after kidney transplantation. A previous meta-analysis reported an association between PTA and graft loss. However, data on cardiovascular outcomes have not yet been reported. We conducted an updated meta-analysis to examine the association between PTA and prognosis in adult kidney transplant recipients.
Methods
We comprehensively searched the databases of MEDLINE and EMBASE from inception to January 2021. Data from each study were combined using the random-effects model.
Results
Seventeen studies from August 2006 to April 2019 were included (16,463 KT recipients). The PTA was associated with overall mortality (pooled RR=1.72 [1.39, 2.13], I2=56%), graft failure (pooled RR=2.28 [1.77, 2.93], I2=94%), cardiovascular death (pooled RR=2.06 [1.35, 3.16], I2=0%), and cardiovascular events (pooled RR=1.33 [1.10, 1.61], I2=0%). Early PTA (≤ 6 months), compared with late PTA (> 6 months), has higher risk of overall mortality and graft loss with a pooled risk ratio of 2.63 (95% CI 1.79-3.86, I2=0%) and 2.96 (95% CI 2.29-3.82, I2=0%), respectively.
Conclusion
Our meta-analysis demonstrates that PTA was significantly associated with overall mortality, graft failure, cardiovascular death, and cardiovascular events.
The association between PTA and overall mortality
The association between PTA and graft loss