Kidney Week

Abstract: PO0054

Temporal Trends in Mortality and Hospitalization Related to SARS-CoV-2 in Dialysis Patients in Québec (Canada)

Session Information

• COVID-19: Epidemiology, Outcomes, Complications, and Risk Factors
  November 04, 2021 | Location: On-Demand, Virtual Only
  Abstract Time: 10:00 AM - 12:00 PM

Category: Coronavirus (COVID-19)

• 000 Coronavirus (COVID-19)

Authors

• Nadeau-Fredette, Annie-Claire, Hopital Maisonneuve-Rosemont Centre de Recherche, Montreal, Quebec, Canada

Annie-Claire Nadeau-Fredette, MD, MS

• Beaubien-Souligny, William, Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada

William Beaubien-Souligny,

• Mac-Way, Fabrice, CHU de Quebec-Universite Laval, Quebec, Quebec, Canada

Fabrice Mac-Way,

• Goupil, Remi, Hopital du Sacre-Coeur de Montreal Centre de Recherche, Montreal, Quebec, Canada

Remi Goupil,

• Blum, Daniel, McGill University Health Centre, Montreal, Quebec, Canada

Daniel Blum,

• Suri, Rita, McGill University Health Centre, Montreal, Quebec, Canada

Rita Suri,

Group or Team Name

• For the Quebec Renal Network Study Group

Background

In Canada, Quebec province was the most severely hit region during the first year of the SARS-CoV-2 pandemic. We aimed to compare characteristics and outcomes of dialysis patients during the first and second SARS-CoV-2 transmission surges in this province.

Methods

The QRN-COVID-HD study included adult dialysis patients from 13 units in Quebec, with SARS-CoV-2 PCR tests performed between Mar-Sept 2020 (1^st wave) and Oct 2020-Feb 2021 (2^nd wave). Crude and stratified rates of mortality, hospitalization and intensive care unit (ICU) admission within 90-day of SARS-CoV-2 positivity were calculated with mixed effect Poisson regressions. Adjusted predictors of 90-day outcomes were evaluated using mixed effect logistic regressions and negative binomial regressions (as appropriate).

Results

Over this 12-month period, 431 patients were infected with SARS-CoV-2 (211 1^st wave; 220 2^nd wave). Most characteristics (including age) were similar in the two waves although 2^nd wave patients were less frequently living in long-term care facilities and had more diabetic nephropathy. Overall, 214 (50%) patients were hospitalized at least once and 214 (26%) died within 90-day of SARS-CoV-2 positivity, with 78% of hospitalizations and 84% of deaths directly attributed to SARS-CoV-2. Mortality and hospitalization rates were lower for 2^nd compared to 1^st wave patients. Figure In contrast, ICU admissions were similar in both waves (0.14, 95% CI 0.10-0.19 [1^st] vs. 0.13, 95% CI 0.09-0.18 [2^nd] per 100 pt-yrs). When adjusted for case-mixed differences, the 2^nd wave remained associated with lower risk of mortality (OR 0.55, 95% CI 0.32-0.95), hospitalization (OR 0.45, 95%CI 0.28-0.71) and days in hospital (IRR 0.49, 95% CI 0.46-0.53), but similar risk of ICU (OR 0.73; 95% CI 0.39-1.37).

Conclusion

Dialysis patients with SARS-CoV-2 infections had more favorable clinical outcomes during the 2^nd wave, which is consistent with observations in the general population and may be related to improved clinical care.

Funding

• Government Support – Non-U.S.