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Abstract: PO0208

An Analysis of Risk Factors for AKI in Patients with Decompensated Cirrhosis: A 4-Year Retrospective Study, 2012-2015

Session Information

Category: Acute Kidney Injury

  • 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

  • Xu, Youjun, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Luo, Lianxin, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Zhou, Fangfang, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Han, Lina, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Chen, Yixin, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Lu, Yi, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
  • Luo, Qun, Department of nephrology, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, China
Background

Acute kidney injury (AKI) is a common complication in advanced liver diseases. So prevention of AKI occurence in patients with cirrhosis might improve their outcomes. We aimed to determine the risk factors for AKI in patients with decompensated cirrhosis.

Methods

We conducted a retrospective analysis, which was a 4-year study involving 945 patients. AKI was diagnosed based on 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. The clinical and demographic data of AKI group was compared with other patients by univariate and multivariate regression analyses.

Results

The incidence of AKI in decompensated cirrhosis was 17.7%. Compared with patients without AKI, patients with AKI had higher white blood cell (WBC) count, longer prothrombin time (PT), higher total bilirubin (TBil), higher serum creatinine (SCr) and higher blood urea nitrogen (BUN), but having lower alanine aminotransferase (ALT), lower albumin, lower cholinesterase (ChE), lower estimated glomerular filtration rate (eGFR), lower total cholesterol (TC) , lower triglyceride (TG) and lower serum sodium concentration. But no significant differences in platelet(PLT) count and International Normalized Ratio (INR). In the multivariate logistic regression analysis, hypertension(odds ratio [OR] :3.647, 95% confidence interval [CI]:1.546-8.606, P=0.003), upper gastrointestinal bleeding (OR:4.957, 95%CI:2.177-11.286, P<0.001), SCr(OR:1.019, 95%CI:1.003-1.035, P=0.019), WBC(OR:1.147, 95%CI:1.032-1.275, P=0.011), PT(OR:1.097, 95%CI:1.004-1.198, P=0.04) and eGFR (OR:0.958, 95%CI:0.934-0.983, P=0.001) were independent risk factors for occurrence of AKI in patients with decompensated cirrhosis.

Conclusion

We observed that hypertension, upper gastrointestinal bleeding, SCr, value of WBC count, length of PT and eGFR were independently associated with the development of AKI in patients with decompensated cirrhosis. It is, therefore, necessary to apply early intervention in patients with the risks of AKI.