ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO0851

Association Between Systolic Blood Pressure Changes and Residual Kidney Function Decline Among Hemodialysis Patients After 1 Year

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Morillo, Miguel A., University of California Irvine, Irvine, California, United States
  • Hsiung, Jui-Ting, University of California Irvine, Irvine, California, United States
  • Kovesdy, Csaba P., VA Memphis Medical Center, Memphis, Tennessee, United States
  • Kalantar-Zadeh, Kamyar, University of California Irvine, Irvine, California, United States
  • Streja, Elani, University of California Irvine, Irvine, California, United States
Background

For patients undergoing hemodialysis, large changes in systolic blood pressure (SBP) from before to after the dialysis has been associated with worse survival. Declines in residual kidney function has also been associated with worse survival. However, the association between SBP changes and residual kidney function decline has not yet been examined.

Methods

We constructed a retrospective cohort of 6659 hemodialysis patients who started dialysis between 2007-2011 with data on average baseline changes in SBP and renal urea clearance (KRU) at the 1st and 5th patient quarter (91 day interval from dialysis start). KRU difference was measured as KRU difference between 5th minus 1st patient quarter. The association between baseline average changes in SBP and KRU difference was examined using linear regression analyses. Covariates included age, sex, race, BMI, dialysis modality type, and comorbidities.

Results

Linear regression analysis indicated a linear relationship between change in SBP and KRU decline even after adjusting for covariates. Trends across all models showed hemodialysis patients with increased systolic blood pressure showed increased residual kidney function compared to the reference (-10 to -0 mmHg). After adjusting for covariates, hemodialysis patients with SBP levels that increased by 10mmHg or more had the greatest increase of KRU (0.12, 95% CI (-0.39, -0.62)), while patients with a decrease of SBP by 10-20mmHg had the greatest decline (-0.31, 95% CI (-0.60, 0.02)). Models adjusting for SBP measures showed similar trends, while the model without low-SBP and post-SBP showed an increased in KRU when SBP decreased by 10-20mmHg (0.23, 95% CI (0.01, 0.05).

Conclusion

Increase in SBP was associated with a greater KRU decline in hemodialysis patients. Futher studies should examine the underlying causes of this association and determine if modifications to dialysis treatments can improve preserving KRU and patient survival.