Abstract: PO2141
Airflow Limitation, Fatigue, and Health-Related Quality of Life in Kidney Transplant Recipients
Session Information
- Transplantation: Clinical - Underrecognized Risk Factors, Traditional Considerations, and Outcomes
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Knobbe, Tim J., Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
- Kremer, Daan, Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
- Gan, Tji, Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
- Annema, Coby, Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
- Berger, Stefan P., Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
- Bakker, Stephan J.L., Rijksuniversiteit Groningen, Groningen, Groningen, Netherlands
Background
Many kidney transplant recipients (KTR) suffer from fatigue and poor health-related quality of life (HRQoL). Airflow limitation may be an underappreciated comorbidity among KTR, which could contribute to fatigue and poor HRQoL in this population. In this study, we compared the prevalence of airflow limitation between KTR and healthy controls (HC), and investigated associations of airflow limitation with fatigue and HRQoL in KTR.
Methods
Data from the ongoing TransplantLines Biobank and Cohort Study (NCT03272841) were used. Airflow limitation was defined as forced exhaled volume in one second (FEV1) <5th percentile of the general population. Fatigue and HRQoL were assessed using CIS20R and SF-36 questionnaires.
Results
A total of 539 KTR (58% male, mean age 56±13 years) and 244 HC (45% male, mean age 57±10 years) were included. Prevalence of airflow limitation was higher in KTR than in HC (133 (25%) vs. 25 (10%), p<0.001). Airflow limitation was independently associated with higher risk of severe fatigue (OR 2.53, 95%CI 1.41 to 4.55, p=0.002) and poor HRQoL (physical component score (PCS): st. β -0.12, 95%CI -0.20 to -0.04, p=0.005 and mental component score (MCS): st. β -0.10, 95%CI -0.19 to -0.01, p=0.034) in KTR. Fatigue mediated the association of airflow limitation with PCS and MCS for 76.2% and 99.6%, respectively (Figure 1).
Conclusion
Airflow limitation is common among KTR. Its occurrence more than doubles the risk of severe fatigue, and is associated with poor HRQoL. Mediation analyses suggest that airflow limitation causes fatigue, which in turn decreases HRQoL. Since airflow limitation can be improved by treatment and training, it may be a promising therapeutic target to reduce fatigue, and consequently to improve HRQoL among KTR.