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Abstract: PO1932

Does Obtaining an Extra Biobank Sample Increase the Risk of Post-Kidney Biopsy Complications? A Single-Center Experience

Session Information

Category: Pathology and Lab Medicine

  • 1600 Pathology and Lab Medicine

Authors

  • Bermejo, Sheila, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • García-Carro, Clara, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Vergara, Ander, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Agraz, Irene, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Mast, Richard, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • León Román, Juan, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Bolufer, Mónica, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Serón, Daniel, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
  • Soler, Maria Jose, Vall d'Hebron Hospital Universitari, Barcelona, Catalunya, Spain
Background

Kidney biopsy(KB) is the “gold standard” for nephropathies diagnosis and it has a low rate of complications. Obtaining material for KB biobank requires the extraction of extra renal cylinder. The objectives of study are to analyze the characteristics of a cohort of patients with KB, the safety and show whether obtaining extra renal cylinder is associated with an increased risk of complications.

Methods

Observational and prospective study of KBs performed in our center during 2019 and 2020. We started a collection of KB samples to biobank at 2019. In patients who accepted, instead of two cylinders, three cylinders were obtained during the procedure. Clinical and laboratory data of patients were reviewed. Risk factors for complications, including the number of cylinders obtained, was also assessed.

Results

221 patients in whom we performed a KB at our hospital were included in the biobank. 8 patients(3.6%) underwent trans-jugular renal biopsy, which we have excluded. Of the remaining 213, 126(59.2%) were men, the mean age 56.8(± 16.9) years, 122(57.3%) patients had hypertension, 46(23%) were diabetics, 14(6.5%) were under anticoagulant treatment and 35(16.4%) under antiplatelet treatment. The mean creatinine was 2.22(±1.9) mg/dl, protein/creatinine urine ratio 1119.6[448.3-2957.9]mg/gr, the hemoglobin pre-KB was 12.1(± 2.3) g/dL, 254380(± 8873) platelets, INR 0.98(± 0.09), prothrombin time 11.8(± 1.16) seconds. 69.5%(n=148) of patients 3 renal cylinders were obtained, 27.2%(n=58) 2 cylinders and in 3.3%( =7) one cylinder. Minor complications were observed in 13.6%(n=29) and major complications in 3.3%(n=7). We observed that patients with complications in KB were younger(p=0.034), had less weight(p=0.022), more transfusions(p=0.003), more platelets(p=0.038), a lower PT(p=0.05) and 1 cylinder was obtained in the KB with more frequency(p=0.012). In a multivariate regression logistic analysis PT (OR:1.497,p=0.042), transfusions(OR:5.38,p=0.032) and 1 cylinder obtained(OR:7.258,p=0.032) were identified as a risk factors of KB complications.

Conclusion

KB is a procedure with a low complication rate. Obtaining three KB cylinders for biobank has not shown an increase in the rate of complications, which in concordance with previous published studies remains low.