Abstract: PO2295
AKI in Rural Workers: Is Mesoamerican Nephropathy in Fact an Agricultural Nephropathy?
Session Information
- CKD: Drugs, Diet, and Other Determinants
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Musso, Carlos Guido, Research Departament. Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Argentina
- Aroca Martinez, Gustavo, Univiersidad Simon Bolivar, Barranquilla, Colombia
- Cadena-Bonfanti, Andres, Univiersidad Simon Bolivar, Barranquilla, Colombia
- Avendaño-Echavez, Lil Geraldine, Univiersidad Simon Bolivar, Barranquilla, Colombia
- Terrasa, Sergio, Research Departament. Hospital Italiano de Buenos Aires, Argentina, Buenos Aires, Argentina
- Velez-Verbel, Maria De los angeles, Clinica de la Costa Ltda, Barranquilla, Atlántico, Colombia
- Peña-Vargas, William Arturo, Hospital la divina misericordia, Cartagena, Colombia
- Perez, Rafael, Univiersidad Simon Bolivar, Barranquilla, Colombia
- Sierra, Angelica, Univiersidad Simon Bolivar, Barranquilla, Colombia
Background
Mesoamerican nephropathy (MN) is a chronic tubule-interstitial nephropathy, originally described in Central America, and whose exact etiology is still unknown. Many inducing factors have been proposed such as severe dehydration, rhabdomyolysis, nephrotoxicity, chronic infections, genetic predisposition, etc. However, similar nephropathies to MN have been described in areas geographically far and ethnically diverse from Mesoamerica but which have a common factor: the intensity of hot weather and rural physical labor. For this reason, we suggest the term “agricultural nephropathy” as more appropriate name for this condition. Then, it was decided to study whether this entity could occur among rural workers of non Mesoamerican region but having similar climatic and working conditions, as is the case of the Colombian Caribbean countryside, and to consider how much repeated dehydration could weigh in its pathogenesis.
Methods
A descriptive, observational, cross-sectional study was carried out, based on field work in a farm in Sitio Nuevo (Magdalena, Colombia) in 28 rural worker volunteers (rice fields), who were measured for weight, blood pressure , blood and urine samples to measure electrolytes and osmolarity, at 2 times of the day (morning and evening).
Results
Of the 28 young men workers evaluated, 5 (18%) presented a significant increase in serum creatinine during the day (0.8±0.15 vs 1.2±0.17, p: 0.001). The volume of water ingested by the workers was highly variable (2,861 ± 1,591 cc). There was a significant increase in serum sodium (p: 0.001), and urinary osmolarity (p: 0.01) values between morning and afternoon values in these 5 patients
Conclusion
Some rural workers developed parameters compatible with AKI and dehydration during their work day in the Colombian Caribbean countryside