Abstract: PO2313
Genetic Variant rs671 of ALDH2 Gene Is Associated with Reduced Renal Function in Chinese Population
Session Information
- CKD: Drugs, Diet, and Other Determinants
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Lin, Jianfeng, Peking Union Medical College Hospital Department of Nephrology, Dongcheng-qu, Beijing, China
- Li, Jing, Peking Union Medical College Hospital Department of Health Care, Dongcheng-qu, Beijing, China
- Li, Jiaying, Peking Union Medical College Hospital Department of Nephrology, Dongcheng-qu, Beijing, China
- Ji, Peili, Peking Union Medical College Hospital Department of Nephrology, Dongcheng-qu, Beijing, China
- Qiu, Ling, Peking Union Medical College Hospital Department of Laboratory Medicine, Dongcheng-qu, Beijing, China
- Xu, Tengda, Peking Union Medical College Hospital Department of Health Care, Dongcheng-qu, Beijing, China
- Chen, Limeng, Peking Union Medical College Hospital Department of Nephrology, Dongcheng-qu, Beijing, China
Background
ALDH2 is a mitochondrial aldehyde dehydrogenase and ALDH2 rs671 genetic polymorphism was associated with hypertension and diabetes. Genome-wide association analysis of East Asians revealed ALDH2 rs671 variant associated with kidney function traits, but comprehensive epidemiological studies are lacking. We conducted this study to explore the associations between ALDH2 rs671 and kidney function traits in Chinese population.
Methods
A total of 15,856 individuals completed medical check-up in a single center were enrolled. ALDH2 gene mutation detection kit was used to genotype the rs671 polymorphism. Clinical laboratory data were collected from the records of medical check-up. Urine albumin creatinine ratio (UACR) was tested in 5,168 individuals and the data was log-transformed for further analysis. Linear and logistic regression analysis were used to estimate the association between rs671 SNP and renal function traits.
Results
The average age was 48.8±9.7 years and the individuals were mainly males (67.0%). 17.7%, 13.0% and 30.6% individuals were obese, diabetic, and hypertensive, respectively. Frequencies of GG, GA, and AA genotypes were 68.0%, 29.4% and 2.6%. Male individuals with A allele were associated with a significant increased level creatinine (β = 1.664, 95% CI: 1.141, 2.186) and blood urea nitrogen (β = 0.156, 95% CI: 0.107, 0.205), and reduced estimated glomerular filtration rate (eGFR, β = -1.057, 95% CI: -1.347, -0.767), uric acid (β = -8.893, 95% CI: -11.908, -5.877), logUACR (β = -0.066, 95% CI: -0.122, -0.011). Similar associations were not observed in female individuals. Besides, we did not observe association between ALDH2 genotype and chronic kidney disease (CKD), albuminuria, or proximal tubular injury.
Conclusion
ALDH2 rs671 polymorphisms were associated with decreased renal function in male individuals other than the females. Further analyses were needed for further explore the direct and indirect effects of ALDH2 SNP on CKD, albuminuria, and proximal tubular injury.
Funding
- Government Support – Non-U.S.