Abstract: PO0514
A 20-lb Portable Continuous Renal Replacement Therapy (PCRRT) Machine Battery Operated Using 300 mL Fluid: CRRT Anywhere, Any Time
Session Information
- Bioengineering: Organoids and Organs-on-a-Chip
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Bioengineering
- 300 Bioengineering
Author
- Gura, Victor, Cedars-Sinai Medical Center, Los Angeles, California, United States
Background
CRRT is challenging due to needing large amounts of sterile fluids excessive labor and cost. Prescribed treatment is frequently interrupted when patients are transported out of the ICU for tests and procedures. Hence the unmet need for a light and portable battery operated CRRT machine that uses less fluids and nursing labor and can be used anytime at any place, including during procedures or transportation.
Methods
The machine connects to a central venous catheter and blood is heparinized and propelled through the blood compartment of a 0.6 sqm dialyzer and recirculated back to the central vein.
300 ml of sterile 0.45 N is circulated into the dialysate compartment of the dialysate. Calcium, magnesium, and sodium bicarbonate are added to the dialysate. Potassium and other additives may also be added. Blood and the dialysate are propelled by a double channel pulsatile pump. The volume of fluid removal is controlled by a volumetric separate pump. The spent dialysate coming out of the dialyzer is circulated through sorbents that regenerate the dialysate allowing for the use of only 300 ml of fluid instead of 30 liters, or more, of sterile fluid. Spent dialysate coming out of dialyzers during treatment of renal failure patients and with added urea, creatinine and lactic acid was circulated through the sorbent canisters. Lactate, urea, creatinine, and electrolytes were measured in the dialysate after recirculating through the sorbents.
Results
Urea, creatinine, potassium, and lactate were undetectable in the dialysate after it recycled through the sorbent canisters.
Conclusion
Less sterile fluid and less nursing labor, make it cost-effective.
Current machines weigh more than 100 pounds, and have a large footprint, making it impossible to use them out of the ICU, or during ambulance or helicopter transportation. This machine, weighs 20 pounds, is battery powered and uses 300 ml of sterile fluid. The size and weight, and sterile fluid requirements allow uninterrupted use in ICU, on a stretcher, during ambulance or aircraft transportation.
Funding
- Other U.S. Government Support –