Abstract: PO2270
Associations Between eGFR and Brain Atrophy
Session Information
- CKD: Associations and Electrolytes
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Grasing, Michael, University of Kansas School of Medicine, Kansas City, Kansas, United States
- Sharma, Palash, University of Kansas Medical Center, Kansas City, Kansas, United States
- Lepping, Rebecca J., University of Kansas Medical Center, Kansas City, Kansas, United States
- Honea, Robyn, University of Kansas School of Medicine, Kansas City, Kansas, United States
- Gupta, Aditi, University of Kansas Medical Center, Kansas City, Kansas, United States
Background
The associations between estimated glomerular filtration rate (eGFR) and both cognitive decline and brain atrophy have been less studied in elderly with kidney disease. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is an NIH funded multicenter observational study characterizing progression of dementia in the elderly. Using the ADNI data, we analyzed the association between eGFR and brain volume.
Methods
We used multiple linear regression model to determine the association between eGFR and normalized (brain region divided by intracranial volume) whole brain and hippocampus volume (primary outcomes) and entorhinal cortex, and middle temporal gyrus volumes (secondary outcomes) as determined by brain MRI.
Results
Mean age of the 1596 ADNI participants was 74 ± 7 years; 53% had mild cognitive impairment (MCI), and 19% had dementia. 27% had eGFR <60 ml/min/1.73m2. Participants with lower eGFR were older and had a higher prevalence of dementia. While increasing age, and female sex were associated with lower brain volumes, lower eGFR was not (table 1). The results persisted in sub analyses divided by tertiles of age in participants with normal cognition, MCI, or dementia.
Conclusion
Low eGFR was not associated with brain atrophy in the ADNI participants with mild-moderate reduction in eGFR.
Multiple linear regression model predicting brain volumes.
| Whole brain | Hippocampus | Entorhinal | Fusiform | Mid Temporal | |
| Age | -3.0e-03 (<0.001) | -3.7e-05 (<0.001) | -1.3e-05 (<0.001) | -6.7e-05 (<0.001) | -5.7e-05 (<0.001) |
| Sex (F) | 1.1e-02 (<0.001) | 2.5e-04 (<0.001) | 3.6e-05 (0.19) | 1.3e-04 (0.16) | 1.7e-04 (0.09) |
| Education | 1.99e-04 (0.64) | 5.2e-06 (0.48) | 1.6e-05 (0.001) | 4.4e-05 (0.01) | 2.9e-05 (0.10) |
| eGFR | 1.4e-04 (0.09) | 1.07e-06 (0.48) | 1.4e-07 (0.89) | -6.6e-07 (0.84) | 2.9e-06 (0.44) |
eGFR; estimated glomerular filtration rate. Values are represented as B estimate (p value)
Funding
- Other NIH Support