Kidney Week

Abstract: PO0096

Three-Month Clinical, Functional, and Mental Outcomes in Kidney Transplant Recipients Surviving COVID-19

Session Information

• COVID-19: Health Systems and More
  November 04, 2021 | Location: On-Demand, Virtual Only
  Abstract Time: 10:00 AM - 12:00 PM

Category: Coronavirus (COVID-19)

• 000 Coronavirus (COVID-19)

Authors

• Duivenvoorden, Raphael, Radboudumc, Nijmegen, Gelderland, Netherlands

Raphael Duivenvoorden, MD, PhD

• Vart, Priya, Universitair Medisch Centrum Groningen, Groningen, Groningen, Netherlands

Priya Vart,

• Noordzij, Marlies, Universitair Medisch Centrum Groningen, Groningen, Groningen, Netherlands

Marlies Noordzij,

• Soares dos Santos Jr, Augusto Cesar, Hospital das Clinicas at Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Augusto Cesar Soares dos Santos Jr,

• Zulkarnaev, Alex B., Moskovskij oblastnoj naucno-issledovatel'skij kliniceskij institut imeni M F Vladimirskogo, Moskva, Moskva, Russian Federation

Alex B. Zulkarnaev,

• Franssen, Casper F.M., Universitair Medisch Centrum Groningen, Groningen, Groningen, Netherlands

Casper F.M. Franssen,

• Kuypers, Dirk R., Katholieke Universiteit Leuven Universitaire Ziekenhuizen Leuven, Leuven, Flanders, Belgium

Dirk R. Kuypers,

• Demir, Erol, Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Istanbul, Turkey

Erol Demir,

• Rahimzadeh, Hormat, Sina Hospital, Tehran, Tehran, Iran (the Islamic Republic of)

Hormat Rahimzadeh,

• Kerschbaum, Julia, Medizinische Universitat Innsbruck Universitatsklinik fur Innere Medizin IV Nephrologie und Hypertensiologie, Innsbruck, Austria

Julia Kerschbaum,

• Jager, Kitty J., Amsterdam Universitair Medische Centra, Duivendrecht, Noord-Holland, Netherlands

Kitty J. Jager,

• Turkmen, Kultigin, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Meram, Konya, Turkey

Kultigin Turkmen,

• Hemmelder, Marc H., Universiteit Maastricht, Maastricht, Limburg, Netherlands

Marc H. Hemmelder,

• Schouten, Marcel, Tergooi, Hilversum, North Holland, Netherlands

Marcel Schouten,

• Rodríguez-Ferrero, María L., Hospital General Universitario Gregorio Maranon, Madrid, Madrid, Spain

María L. Rodríguez-Ferrero,

• Crespo, Marta, Hospital del Mar, Barcelona, Catalunya, Spain

Marta Crespo,

• Gansevoort, Ron T., Universitair Medisch Centrum Groningen, Groningen, Groningen, Netherlands

Ron T. Gansevoort,

• Hilbrands, Luuk, Radboudumc, Nijmegen, Gelderland, Netherlands

Luuk Hilbrands,

Background

Kidney transplant patients are at high risk for COVID-19 related mortality. However, limited data are available on longer term clinical, functional and mental outcomes in patients that survive COVID-19.

Methods

Data from adult kidney transplant patients that presented with COVID-19 between February 1^st, 2020 and January 31^st, 2021 were retrieved from the ERACODA database. Data from patients with complete data for vital status, hospitalization and/or ICU admission was used for this analysis.

Results

912 patients were included with a mean age of 56.7 (±13.7) years. 26.4% were not hospitalized, 57.5% hospitalized, and 16.1% hospitalized and ICU admitted. Three-months survival was 82.3% overall and 98.8%, 84.2% and 49.0% resp. in each group. Three-months acute rejection, need for dialysis / CVVH at any time point, and graft failure occurred in the overall group in 1.0%, 2.6% and 1.8% resp., and in 2.1%, 10.6% and 10.6% of ICU admitted patients resp. Of the surviving patients 83.3% had reached their prior functional status within 3 months. Of patients that had not yet reached their prior functional status, it was expected that 79.6% still would do so within the coming year. 94.4% had reached their prior mental status. Of patients that had not yet reached their prior mental status, it was expected that 80% of patients would do so within the coming year.

Conclusion

In patients alive at three-months follow-up, graft loss was rare, and most patients had reached their pre-COVID-19 functional and mental status.

Table 1

Clinical, functional, and mental outcomes in kidney transplant recipients three months after being diagnosed with COVID-19. Data of 487 patients were available for analysis of graft function related outcomes. Data of 450 patients were available for functional and mental status outcomes.