ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on Twitter

Kidney Week

Abstract: PO0692

The Role of Intestinal Flora in Cinnamaldehyde Alleviating Early Proteinuria in Diabetic Nephropathy

Session Information

Category: Diabetic Kidney Disease

  • 601 Diabetic Kidney Disease: Basic


  • Yin, Huanhuan, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Shi, Xiaoxiao, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Liu, Yan, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Yang, Dan, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China
  • Chen, Limeng, Peking Union Medical College Hospital, Dongcheng-qu, Beijing, China

Intestinal dysbiosis played a crucial role in chronic inflammation of diabetic nephropathy (DN). Cinnamaldehyde (CIN) is a traditional natural food addictive from a Chinese herb, recognized as antidiabetic and antibacterial medicine recently. This study was to observe the effects of CIN on renal injury and intestinal flora in DN.


A total of four groups of rats included DN group induced by streptozotocin (70mg/kg), treated with CIN (DNC), control (NC), and NC treated with CIN (NCC). CIN was given daily for 8 weeks. Blood glucose, bodyweight, 24h urinary volume(24hV), protein (24hUP), the pathology changes of kidney, and the protein expression of Megalin, Fibronectin, TGF-β were measured. We also sequenced 16S rDNA of the intestinal flora of the rats.


Compared with DN, DNC showed significant improvement with lower 24hUP, decreased TBM thickness, Fibronectin, TGF-β, and increased Megalin. Simpson’s diversity index of the intestinal flora significantly decreased in the DNC group. PCoA (Fig. A) showed different patterns of clustering between the 4 groups (p<0.01). At genera, compared with NC, g__Lactobacillus decreased significantly in DN, but recoverd in DNC, and it was also confirmed as significant biomarkers by LEfSe (Fig. B). Besides g__Lactobacillus, there were 12 other differentially enriched genera in DNC, such as g__Alloprevotella,and g__Oscillospira. At species, 3 species decreased in DN and recovered in DNC, including s__Bacteroides_massiliensis, s__Oscillibacter_sp_ER4,and s__Lachnospiraceae_ bacterium_ A2. They were anti-inflammatory probiotics that produce short-chain fatty acids. The abundance of 6 genera correlated well with 24hUP (p<0.05, Fig.C). Tax4fun (Fig.D) showed significant differentially enriched functional categories.


Cinnamaldehyde could alleviate renal injury in DN, which was associated with the recovery of the reduced intestinal g__Lactobacillus.