Abstract: PO0924
Urea Clearance Performance in a Modified Batch Dialysis System
Session Information
- Leveraging Technology and Innovation to Predict Events and Improve Dialysis Delivery
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Poppe, Clayton, Diality Inc, Irvine, California, United States
- Hyun, Nicholas, Diality Inc, Irvine, California, United States
- Nash, Sean C., Diality Inc, Irvine, California, United States
- Yeung, Melany, Diality Inc, Irvine, California, United States
- Borrillo, Brandon D., Diality Inc, Irvine, California, United States
- Khawar, Osman, Diality Inc, Irvine, California, United States
Background
Urea clearance is the key measure of dialysis adequacy. The Diality Hemodialysis Machine will provide good clearance performance to ensure an adequate dose of dialysis.
Specific Aims: To assess clearance performance during simulated dialysis utilizing a novel modified batch process. In this setup, dialysis was conducted by alternating dialysate delivery from subsequent two-liter reservoirs.
Methods
Simulated dialysis sessions were conducted utilizing blood flowrates of 300 ml/min, dialysate flowrates of 500 ml/min and no ultrafiltration. Dialysis occurs off of a two-liter batch of dialysate. Once two liters of dialysate has been circulated through the dialyzer, the spent dialysate is discarded and dialysis switches to a separate two-liter reservoir of dialysate while the first reservoir is drained and filled with fresh dialysate. A single compartment simulated patient was created by combining 50 L of DI water with a 20mM concentration of urea. Simulated blood samples were collected at the dialyzer inlet and outlet and dialysate samples collected at the dialyzer outlet to determine urea concentrations over the course of the simulated treatment.
Results
The results are provided in Figure 1. The urea concentrations in the blood decreased over the course of treatment as expected given the stated clearance values of the dialyzer used in the simulated treatment.
Conclusion
The initial experiments using a modified batch system show promising urea clearance. Future tests will better characterize performance compared with conventional devices that do not use a modified batch configuration.
Funding
- Commercial Support –