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Abstract: PO0924

Urea Clearance Performance in a Modified Batch Dialysis System

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Poppe, Clayton, Diality Inc, Irvine, California, United States
  • Hyun, Nicholas, Diality Inc, Irvine, California, United States
  • Nash, Sean C., Diality Inc, Irvine, California, United States
  • Yeung, Melany, Diality Inc, Irvine, California, United States
  • Borrillo, Brandon D., Diality Inc, Irvine, California, United States
  • Khawar, Osman, Diality Inc, Irvine, California, United States
Background

Urea clearance is the key measure of dialysis adequacy. The Diality Hemodialysis Machine will provide good clearance performance to ensure an adequate dose of dialysis.

Specific Aims: To assess clearance performance during simulated dialysis utilizing a novel modified batch process. In this setup, dialysis was conducted by alternating dialysate delivery from subsequent two-liter reservoirs.

Methods

Simulated dialysis sessions were conducted utilizing blood flowrates of 300 ml/min, dialysate flowrates of 500 ml/min and no ultrafiltration. Dialysis occurs off of a two-liter batch of dialysate. Once two liters of dialysate has been circulated through the dialyzer, the spent dialysate is discarded and dialysis switches to a separate two-liter reservoir of dialysate while the first reservoir is drained and filled with fresh dialysate. A single compartment simulated patient was created by combining 50 L of DI water with a 20mM concentration of urea. Simulated blood samples were collected at the dialyzer inlet and outlet and dialysate samples collected at the dialyzer outlet to determine urea concentrations over the course of the simulated treatment.

Results

The results are provided in Figure 1. The urea concentrations in the blood decreased over the course of treatment as expected given the stated clearance values of the dialyzer used in the simulated treatment.

Conclusion

The initial experiments using a modified batch system show promising urea clearance. Future tests will better characterize performance compared with conventional devices that do not use a modified batch configuration.

Funding

  • Commercial Support