ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005

email@asn-online.org

202-640-4660

The Latest on Twitter

Kidney Week

Abstract: PO0892

Hyperkalemia: Medical Management vs. Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Gotesman, Joseph Aaron, Lenox Hill Hospital, New York, New York, United States
  • DeVita, Maria V., Lenox Hill Hospital, New York, New York, United States
Background

Hyperkalemia is a life-threatening electrolyte disorder for which there exists a paucity of data regarding benefit of urgent hemodialysis over medical management. We hypothesized there would be no difference in potassium levels among hyperkalemic patients who received only medical management compared to those who received hemodialysis, with out without hemodialysis.

Methods

This is a retrospective study of patients 18+ years old with hyperkalemia (K > 5.5mmol/L). One group (medical management, or MM) had medication(s)—including insulin/dextrose, sodium zirconium cyclosilicate, sodium polystyrene sulfonate, calcium gluconate, albuterol, or furosemide—ordered within 3h of initial elevated potassium. The other group (hemodialysis, or HD), had hemodialysis ordered—with or without medical management—within 3h of elevated potassium. The initial potassium level was considered “time-zero” and subsequent timepoints were followed up to 100h. T1 readings were established between 0–3 hours; T6: 3–8h; T12: 8–16h; T24: 20–28h; T48: 40–56h; T72: 60–100h.

Results

Of 1365 patients screened between 2015 and 2020, we excluded 796 who were <18 years old or potassium level <5.5 mmol/L or without follow-up potassium levels. There were in-total 569 patients with 682 eligible patient visits; 64 (9%) of the 682 visits in HD group and 618 (91%) in MM group. The mean initial potassium was 6.45 ± 0.08 mmol/L in HD, versus 6.21 ± 0.03 mmol/L in MM. There was a progressive reduction in potassium levels over time in both groups. The reduction in potassium was similar in both groups across all timepoints (4.5-5.0 mmol/L in HD and 4.4-5.1 mmol/L in MM). The only timepoint that showed statistical difference was T12 where potassium level in HD was lower than in MM by 0.45 mmol/L (p-value = 0.0153). This may be secondary to the efficiency and permanence of potassium removal with dialysis or due to the relatively small sample size of the HD group; this difference is not clinically relevant.

Conclusion

Among patients presenting with hyperkalemia, we found no difference in potassium levels between those who received only medical management and those who received hemodialysis, with or without medical management. Further studies are necessary to confirm these findings. Nationally standardized treatment algorithms ought to be developed; a randomized trial would be conducive to that end.