Abstract: PO2234
Comparison of Clinical Features of Pregnant and Non-Pregnant Women with Primary Hyperoxaluria
Session Information
- Advances in Women's Health and Kidney Diseases
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Women’s Health and Kidney Diseases
- 2000 Women’s Health and Kidney Diseases
Authors
- Miao, Jing, Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
- Mehta, Ramila A., Mayo Clinic Division of Biostatistics, Rochester, Minnesota, United States
- Norby, Suzanne M., Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
- Seide, Barbara M., Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
- Andrist, Genia, Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
- Milliner, Dawn S., Mayo Clinic Division of Pediatric Nephrology, Rochester, Minnesota, United States
- Lieske, John C., Mayo Clinic Department of Laboratory Medicine and Pathology, Rochester, Minnesota, United States
- Kattah, Andrea G., Mayo Clinic Division of Nephrology and Hypertension, Rochester, Minnesota, United States
Background
Primary hyperoxaluria (PH) is a rare monogenic disease characterized by oxalate overproduction in the liver, hyperoxaluria, and risk of kidney stones and chronic kidney disease. Data about the effects of pregnancy on women with PH are lacking. We aimed to compare clinical features and risk of incident kidney failure in women with PH with and without pregnancy.
Methods
Women with PH were identified from the Rare Kidney Stone Consortium registry, and pregnancy was identified by phone interview and medical record review. Kidney survival and risk of time-dependent kidney failure were estimated using the Kaplan-Meier method and adjusted proportional hazard Cox’s model.
Results
We identified 47 women with PH and a history of pregnancy and 39 women without pregnancy. PH was diagnosed later in women with pregnancy vs. women without pregnancy (median age 32.4 vs. 13.4 years, p<0.001). Other clinical characteristics such as PH type, eGFR and 24-hour urine oxalate excretion (U[ox]) at PH diagnosis did not differ between the 2 groups. Fig 1A shows the time course of the PH diagnosis, pregnancy and kidney failure in 29 women with known delivery date. In women with pregnancy versus non-pregnancy, the hazard ratio for incident kidney failure was 0.81 (95% CI 0.25-2.6, p=0.73) when adjusted for PH type, age, and eGFR and U[ox] at PH diagnosis. Among patients with PH1 who did not have kidney failure by the time of the 1st pregnancy (n=20), kidney survival estimates at 10, 20, and 30 years after delivery were 79%, 60%, and 45%, respectively (Fig 1B).
Conclusion
These results suggest that pregnancy did not greatly impact renal prognosis in women with PH.
Fig 1. Time from first and last pregnancy to PH diagnosis and kidney failure in 29 women (A) and Kaplan-Meier plots of renal survival in PH1 patients who did not have kidney failure by the time of the 1st pregnancy (B).
Funding
- Other NIH Support –