Abstract: PO1759
Blood Pressure Trends in a Cohort of 9- and 10-Year-Old Children in Iceland: A 10-Year Follow-Up Study
Session Information
- Hypertension and CVD: New insights
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1401 Hypertension and CVD: Epidemiology, Risk Factors, and Prevention
Authors
- Sigurdardottir, Asdis H., Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland
- Indridason, Olafur S., Division of Nephrology, Landspitali –The National University Hospital of Iceland, Reykjavik, Iceland
- Stephensen, Sigurdur S., Children’s Medical Center, Landspitali –The National University Hospital of Iceland,, Reykjavik, Iceland
- Hrafnkelsdottir, Thordis J., Division of Cardiology, Landspitali–The National University Hospital of Iceland, Reykjavik, Iceland
- Edvardsson, Vidar O., Children’s Medical Center, Landspitali –The National University Hospital of Iceland,, Reykjavik, Iceland
Background
Although there is significant evidence for an association between childhood and adult office blood pressure (BP), data on the correlation of childhood BP and ambulatory BP (ABP) in young adults are missing. The aim of this study was to examine the association between childhood office BP and both ABP and office BP indices in young adults.
Methods
Subjects were recruited from a cohort of 970 young adults aged 20-21-years who participated in a population-based study of BP in 9-10-year-old Icelandic school children. All participants underwent a minimum of 4 resting BP measurements at the childhood BP screening. A total of 121 individuals have completed their participation in the follow-up study, which included office and ambulatory BP measurements. Pearson correlation and linear regression analysis were used to examine the relationship between childhood and follow-up BP.
Results
A significant positive correlation was observed between childhood mean systolic BP (SBP) and systolic office and ambulatory BP at follow-up (r=0.386, p<0.001 and r=0.370, p<0.001, respectively). The correlation between childhood mean systolic office BP and follow-up mean systolic office BP was stronger for males (r=0.580, p<0.001) than for females (r=0.298, p=0.012), and the same applied for mean systolic ABP (r=0.491, p<0.001 and r=0.323, p=0.006, respectively). The correlation of mean childhood diastolic office BP (DBP) with mean DBP indices at follow-up was insignificant for males (office DBP: r=0.244, p>0.05; ABP: r=0.258, p>0.05) but remained significant for females (office DBP: r=0.355, p=0.0026; ABP: r=0.449, p<0.001). In adjusted analysis, childhood mean office SBP significantly associated with mean office SBP at follow-up in both males (beta=0.69, p<0.001) and females (beta=0.26, p<0.001). Each mmHg increment in mean childhood office SBP predicted an increase of mean ambulatory SBP by 0.52 mmHg (p<0.001), unaffected by sex. Childhood DBP did not significantly predict office or ambulatory BP at follow-up in adjusted analysis.
Conclusion
These preliminary results indicate that childhood SBP significantly predicts both systolic office and ambulatory SBP in young adults and these associations are stronger in males.
Funding
- Government Support – Non-U.S.