Abstract: PO2244
Elevated Triglyceride-Glucose Index Predicts Renal Hyperfiltration in Young Adults
Session Information
- CKD: Associations and Electrolytes
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Oh, Donghwan, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Lee, Kang Yoon, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Yang, Eunji, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Park, Hyeong cheon, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Choi, Hoon Young, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
- Jhee, Jong Hyun, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
Background
Insulin resistance increases the risk for renal hyperfiltration (RHF), a proposed mechanism for kidney injury in diabetes. However, the association between triglyceride-glucose (TyG) index, a novel marker for insulin resistance, and RHF is not well established in young adults. This study aimed to investigate the association between TyG index and RHF in Korean young adults.
Methods
Data were retrieved from the Korean National Health and Nutrition Examination Surveys (2010-2019). A total of 15,764 participants aged 19~39 years with normal kidney function were enrolled. The participants were divided into tertile based on TyG index [ln(fasting triglyceride[mg/dL] x fasting glucose [mg/dL]/2)]. RHF was defined as eGFR with residuals >90th percentile after adjusting for sex, age, weight, and height.
Results
The mean age of the study participants was 30.4± 6.1 years, and 43.8% were male. The mean levels of TyG index were 7.70±0.25, 8.28±0.15 and 9.07±0.45 in tertile 1,2, and 3 respectively. The prevalence of RHF was significantly higher tertile (9.1%, 10.0%, and 10.9%, respectively, P for trend= 0.03). When the association between TyG index and the risk for RHF was evaluated by multivariable logistic regression analysis, the higher tertiles showed increased risks for RHF compared to lowest tertile. (odds ratio [OR],1.24; 95% confidence interval [CI],1.08-1.41, P=0.002 in tertile 2 and OR,1.64; 95%CI, 1.41-1.90, P<0.001 in tertile 3). This association was consistent when TyG index was treated as continuous variable (OR, 1.53; 95% CI, 1.39-1.38; P<0.001). When subgroup analysis stratified by hypertension or diabetes were performed, no significant interactions were found, suggesting TyG index is an independent predictor for RHF regardless of hypertension or diabetes.
Conclusion
This study showed that higher TyG index is associated with increased risk of RHF in Korean young adults with normal kidney function. Longitudinal studies are need to investigate whether elevated TyG index levels associated RHF is an early risk factor for kidney injury in young adults.