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Abstract: PO2303

Association Between the Triglyceride-Glucose (TyG) Index and Coronary Artery Calcification Progression in Non-Diabetic CKD

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Lee, Kang Yoon, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
  • Oh, Donghwan, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
  • Yang, Eunji, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
  • Park, Hyeong cheon, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
  • Jhee, Jong Hyun, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
  • Choi, Hoon Young, Gangnam Severance Hospital, Seoul, Korea (the Republic of)
Background

Patients with chronic kidney disease (CKD), the likelihood of complications of cardiovascular disease(CVD) may increase compared to general population. Quantity of coronary artery calcification (CAC) correlates with atherosclerotic plaque burden and increased quantity of CAC indicates a substantially increased cardiovascular events. In previous studies, the TyG index has been reported to associated with coronary artery calcification aggravation. We investigated whether the TyG index was related to coronary artery calcification aggravation in patients with mild renal insufficiency.

Methods

This retrospective longitudinal study included adult participants who voluntarily underwent at least two cardiac CT examination at the single center, between January 2006 and Octorbor 2018(n=1,516). The TyG index was determined using ln (fasting triglycerides [mg/dL] X fasting glucose [mg/dL]/2). Mean arterial pressure (MAP) was calculated as DBP + ((SBP – DBP)/3). Mild renal insufficiency CKD was defined as 60≤ eGFR ≤ 90ml/min/1.73m2 by the Chronic Kidney Disease Epidemiology Collaboration equation (mild-CKD group). CAC aggravation was defined as an increased coronary artery calcification score (CACS) in the in the follow-up period. To calculate the odds ratio for incident CKD, logistic regression analyses were performed.

Results

1,516 patients were enrolled, of which 746 were in the mild-CKD group without diabetes. The CACS aggravation was significantly higher in participants with a tyG index of 8.9 or higher [OR 1.705 (1.351-2.152), P-value <0.001]. After adjusting for age, sex, MAP, Hemoglobin, Ca X P, potassium associated with increased risk of CAC in participants with mild renal insufficiency [OR 1.534 (1.058-2.224), P=0.027].

Conclusion

Among mild CKD without diabetes, TyG index of 8.9 or higher had a positive correlation with CAC progression.