Kidney Week

Abstract: PO1757

In Vivo Muscle Mitochondrial Function Is Associated with Exercise Capacity and Efficiency in CKD

Session Information

• Health Maintenance, Nutrition, and Metabolism
  November 04, 2021 | Location: On-Demand, Virtual Only
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1300 Health Maintenance, Nutrition, and Metabolism

Authors

• Vargas, Chenoa R., University of California Davis Department of Internal Medicine, Sacramento, California, United States

Chenoa R. Vargas

• Begue, Gwenaelle, California State University Sacramento, Sacramento, California, United States

Gwenaelle Begue,

• Rehman, Usman, University of California Davis, Davis, California, United States

Usman Rehman,

• Ahmadi, Armin, University of California Davis, Davis, California, United States

Armin Ahmadi,

• Kim, Tae Youn, University of California Davis Department of Internal Medicine, Sacramento, California, United States

Tae Youn Kim,

• Jin, Seung Mi, University of California Davis, Davis, California, United States

Seung Mi Jin,

• Gamboa, Jorge, Vanderbilt University, Nashville, Tennessee, United States

Jorge Gamboa,

• Jue, Thomas, University of California Davis, Davis, California, United States

Thomas Jue,

• Roshanravan, Baback, University of California Davis Department of Internal Medicine, Sacramento, California, United States

Baback Roshanravan,

Background

CKD is associated with skeletal muscle dysfunction increasing risk for frailty. Muscle mitochondrial dysfunction may underly impaired physical performance. The associations of in vivo muscle mitochondrial function with exercise capacity and efficiency in CKD is unknown.

Methods

We recruited 8 diabetic and 6 non-diabetic patients with CKD. Leg muscle mitochondrial oxidative capacity was measured by exercise recovery kinetics of [PCr] using ³¹Phosphorus Magnetic Resonance Spectroscopy (³¹P MRS). Cardiorespiratory fitness (CRF, VO₂peak), total work, and work efficiency (total work/VO2peak) were assessed by cycle ergometry. We tested associations of ³¹P MRS measures with endpoints using Pearson correlations.

Results

Participants had a mean age was 61±10yrs, eGFR of 35±12ml/min with 43% females. Faster PCr recovery rate correlated with VO₂ peak (r=0.58, p=0.03), total work (r=0.70, p=0.03) and work efficiency (r=0.59, p=0.03) (Figure). Associations of PCr recovery with work and work efficiency were independent of age, sex, and weight (both p=0.03).

Conclusion

Muscle mitochondrial oxidative capacity is a major determinant of exercise efficiency and capacity. Therapeutics targeting muscle mitochondria function in CKD may improve physical performance and CRF.

Funding

• NIDDK Support