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Abstract: PO1757

In Vivo Muscle Mitochondrial Function Is Associated with Exercise Capacity and Efficiency in CKD

Session Information

Category: Health Maintenance, Nutrition, and Metabolism

  • 1300 Health Maintenance, Nutrition, and Metabolism

Authors

  • Vargas, Chenoa R., University of California Davis Department of Internal Medicine, Sacramento, California, United States
  • Begue, Gwenaelle, California State University Sacramento, Sacramento, California, United States
  • Rehman, Usman, University of California Davis, Davis, California, United States
  • Ahmadi, Armin, University of California Davis, Davis, California, United States
  • Kim, Tae Youn, University of California Davis Department of Internal Medicine, Sacramento, California, United States
  • Jin, Seung Mi, University of California Davis, Davis, California, United States
  • Gamboa, Jorge, Vanderbilt University, Nashville, Tennessee, United States
  • Jue, Thomas, University of California Davis, Davis, California, United States
  • Roshanravan, Baback, University of California Davis Department of Internal Medicine, Sacramento, California, United States
Background

CKD is associated with skeletal muscle dysfunction increasing risk for frailty. Muscle mitochondrial dysfunction may underly impaired physical performance. The associations of in vivo muscle mitochondrial function with exercise capacity and efficiency in CKD is unknown.

Methods

We recruited 8 diabetic and 6 non-diabetic patients with CKD. Leg muscle mitochondrial oxidative capacity was measured by exercise recovery kinetics of [PCr] using 31Phosphorus Magnetic Resonance Spectroscopy (31P MRS). Cardiorespiratory fitness (CRF, VO2peak), total work, and work efficiency (total work/VO2peak) were assessed by cycle ergometry. We tested associations of 31P MRS measures with endpoints using Pearson correlations.

Results

Participants had a mean age was 61±10yrs, eGFR of 35±12ml/min with 43% females. Faster PCr recovery rate correlated with VO2 peak (r=0.58, p=0.03), total work (r=0.70, p=0.03) and work efficiency (r=0.59, p=0.03) (Figure). Associations of PCr recovery with work and work efficiency were independent of age, sex, and weight (both p=0.03).

Conclusion

Muscle mitochondrial oxidative capacity is a major determinant of exercise efficiency and capacity. Therapeutics targeting muscle mitochondria function in CKD may improve physical performance and CRF.

Funding

  • NIDDK Support