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Abstract: PO1799

Circulating Vascular Adhesion Protein-1 Level Predicts Risk of Cardiovascular Events and Mortality in Hemodialysis Patients

Session Information

Category: Hypertension and CVD

  • 1402 Hypertension and CVD: Clinical, Outcomes, and Trials

Authors

  • Kim, Dae Kyu, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Lee, Yu ho, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)
  • Yoon, Soo-Young, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Kim, Jongho, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Kim, Jin sug, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Kim, Yang gyun, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Lee, So-young, CHA Bundang Medical Center, Seongnam, Gyeonggi-do, Korea (the Republic of)
  • Ahn, Shin-Young, Korea University Medical Center, Seoul, Korea (the Republic of)
  • Kang, Shinyeong, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Lee, Dong-Young, Korea Veterans Health Service, Seoul, Korea (the Republic of)
  • Jeong, Kyung hwan, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Moon, Ju young, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Hwang, Hyeon Seok, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
  • Lee, Sangho, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
Background

Vascular adhesion protein-1 (VAP-1) is an oxidative enzyme of primary amines that facilitates the transmigration of inflammatory cells. The oxidative and inflammatory effects of VAP-1 are prominently increased in pathological conditions such as metabolic, atherosclerotic, and cardiac diseases. However, the clinical significance of circulating VAP-1 levels in hemodialysis (HD) patients is unclear.

Methods

A total of 434 HD patients were prospectively enrolled between June 2016 and April 2019 as part of a prospective multicenter cohort study. Plasma VAP-1 levels were measured at the time of study data entry, and the primary endpoint was defined as a composite of cardiovascular (CV) events and cardiac events.

Results

Circulating VAP-1 levels were positively correlated with plasma levels of cardiac remodeling markers, including brain natriuretic peptides, galectin-3, and matrix metalloproteinase-2. Multivariate logistic regression analysis revealed that patients with higher circulating VAP-1 levels were more likely to have left ventricular (LV) diastolic dysfunction (odds ratio, 1.40; 95% confidence interval [CI], 1.04–1.88). The cumulative event rate of the composite of CV events was significantly greater in VAP-1 tertile 3 than in VAP-1 tertiles 1 and 2 (P = 0.009). Patients with VAP-1 levels in tertile 3 were also associated with an increased cumulative event rate of cardiac events (P = 0.015). The VAP-1 tertile 3 was associated with a 2.06-fold higher risk of the composite of CV events (95% CI, 1.10–3.85) and 2.06-fold higher risk of cardiac events (95% CI, 1.03–4.12) after adjustment for multiple variables.

Conclusion

Plasma VAP-1 levels had the positive relationship with circulating levels of cardiac pathology markers and LV diastolic dysfunction. Higher VAP-1 levels were also associated with an increased risk of incident CV events and cardiac events in HD patients. Our results indicate that VAP-1 help clinicians identify those at high risk of CV events