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Abstract: PO2306

Prevalence and Associated Factors for CKD in Rural and Peri-Urban Bangladesh

Session Information

Category: CKD (Non-Dialysis)

  • 2101 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention

Authors

  • Sarker, Mohammad Habibur rahman, Hiroshima Daigaku Igakubu Hoken Gakka, Hiroshima, Japan
  • Moriyama, Michiko, Hiroshima Daigaku Igakubu Hoken Gakka, Hiroshima, Japan
  • Rahman, Md Moshiur, Hiroshima Daigaku Igakubu Hoken Gakka, Hiroshima, Japan
  • Chisti, Mohammod Jobayer, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
  • Faruque, Asg, International Centre for Diarrhoeal Disease Research Bangladesh, Dhaka, Dhaka District, Bangladesh
Background

Chronic Kidney Disease (CKD) is an increasing public health threat worldwide. Studies have documented CKD among adult population in urban Bangladesh, however, in rural and peri-urban settings still lagging behind. We aimed to generate data in understanding the prevalence and CKD-related factors.

Methods

We recruited participants randomly from the Demographic Surveillance System of Mirzapur, Bangladesh in two phases. In phase 1, we screened participants using a laboratory-based creatinine and albumin to creatinine ratio (ACR) and collected information on socio-demographic, lifestyles, and health histories. We evaluated the participants’ CKD status following the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and their estimated glomerular filtration rate (eGFR). Those participants who had eGFR below 60 ml/min/1.73 m2 and/or ACR ≥30 mg/g were considered for phage 2. After three months, in phase 2, we repeated the blood and urine test for GFR and ACR. A participant was diagnosed as a case of CKD if (s)he had eGFR below 60 ml/min/1.73 m2 or had ACR ≥30 mg/g for more than three months as suggested by the Kidney Disease Outcomes Quality Initiative guidelines.

Results

We enrolled 928 participants; of them 872 completed the study procedure and included in the analysis. The mean ± standard deviation (SD) of age was 48.2 ± 16.4. In phase 1, probable CKD cases were 281 (32%), however, in phase 2, confirmed cases were 192 (22%) [stage-1, 4.0%; stage-2, 11.8%; stage-3, 5.5%; stage-4, 0.6%; stage-5, 0.11%]. In the multivariate logistic regression analysis, associated factors for prevalent CKD included aged ≥60 years (adjusted odds ratio [aOR], 5.02; 95% confidence interval [95% CI], 1.85 to 13.65), hypertension (aOR, 3.08; 95% CI, 2.07 to 4.59), diabetes (aOR, 2.52; 95% CI, 1.60 to 3.96), anemia (aOR, 2.50; 95% CI, 1.63 to 3.84) and presence of RBC in urine (aOR, 3.20; 95% CI, 1.71 to 5.98).

Conclusion

In rural and peri-urban Bangladesh, this is the first study of CKD prevalence, and repeated confirmatory testing revealed a prevalence of approximately 22%, which is higher than in urban setting. Findings suggested that CKD monitoring systems are required to assess the overall burden and effective steps should be taken to mitigate these major risk factors.