Abstract: PO2081
Short-Term Fast Does Not Alter Physiological Parameters in Living Kidney Donors
Session Information
- Transplantation: Clinical - Allocation, Evaluation, Prognosis, and Viral Onslaughts
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 1902 Transplantation: Clinical
Authors
- Tzukert, Keren, Hadassah Medical Center, Jerusalem, Israel
- Abel, Roy, Hadassah Medical Center, Jerusalem, Israel
- Ben-Dov, Iddo Z., Hadassah Medical Center, Jerusalem, Israel
- Dranitzki Elhalel, Michal, Hadassah Medical Center, Jerusalem, Israel
Background
Living kidney donation is widely practiced and short and long-term outcomes are acceptable. Within the living Kidney donor population there are unique ethnic groups, such as Jewish or Muslim individuals, who practice customs that may affect kidney function. In Judaism, YOM KIPPUR (Day of Atonement) is a 25-26 hr fast practiced yearly. This fast, revered and practiced by secular and religious Jews, has enormous cultural significance. There are no studies that describe the effect of this fast on LKD's. We aim to compare kidney function and physiological parameters between healthy controls and LKD’s
Methods
LKD's were approached via e-mail. Exclusion criteria were conditions considered prohibitive of fasting. Controls were potential LKD's that have been approved by the standard medical evaluation but have not yet donated. Blood and urine samples were obtained at three time points: Baseline –3 months before fast, Fasting: 1 hr after 24 hr fast, Follow up - 14 days after fast.
Results
85 LKD's & 27 controls were included. Donors were older (42.8 vs. 38.8 years) and had a higher baseline creatinine (103 vs. 72 umol/L). All other parameters were the same. The change between fasting and non-fasting creatinine was smaller in LKD's than in controls (0.12 vs. 0.21% change P=0.04). Values of sodium, albumin & osmolarity were not different between groups. Time from donation did not influence these results
Conclusion
LKD's practicing a 24 hr fast show a different pattern from controls regarding the change in creatinine levels. This pattern cannot be considered hazardous for LKD's. The emotional wellbeing of LKD's is of utmost importance and this first report of the safety of a 24 hour fast is reassuring. These findings may be of interest to other religious groups, e.g. the Muslim community who practice RAMADAN. Further follow-up is needed to explore the long term effects of a 25-26 fast in the LKD population