Abstract: PO1568
Year of Life Lost due to Premature Death from Glomerulonephritis in Thailand
Session Information
- Glomerular Diseases: Clinical Features and Outcomes in Nephrotic Syndromes and Complement-Mediated Diseases
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1203 Glomerular Diseases: Clinical, Outcomes, and Trials
Authors
- Janphram, Chitimaporn, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
- Worawichawong, Suchin, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
- Boongird, Sarinya, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
- Udomsubpayakul, Umaporn, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
- Assanatham, Montira, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
- Kitiyakara, Chagriya, Mahidol University Faculty of Medicine Ramathibodi Hospital, Bangkok, Bangkok, Thailand
Background
The contribution of Glomerulonephritis (GN) on mortality is not fully known.The impact of each GN subtype on premature mortality can be measured by calculating the year of life lost (YLL), which takes into account the age at which deaths occur. Therefore, this study aimed to estimate premature mortality in GN using the average YLL.
Methods
In this retrospective study, we estimated the average YLL in each glomerular disease. The YLL is the difference between age at death and the standard life expectancy of an individual at the same age. To calculate YLL, we retrieved data from Ramathibodi Hospital Glomerular Registry during January 2011 to December 2020 and national data of standard life expectancy 2020. Individual deaths and date were obtained from the National Death Registry office. The average YLL is obtained by dividing total YLL by the total patients in each GN type. GN were categorized into primary GN (IgA nephropathy (IgAN), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MGN) and minimal change disease (MCD)), and secondary GN (lupus nephritis(LN), ANCA-GN, infection related GN (iGN) or MPGN, and diabetic nephropathy (DN).
Results
A total of 1,022-kidney biopsies was performed. The median follow-up time was 67 (IQR 45, 92) months. Age for GN patients was 43.9 ± 16.7 years and 44.8 % males. The total and average YLL of all GN were 4741.9 years and 4.64 years, respectively. The average YLL for secondary GN (n = 391) was higher than primary GN (n = 469) being 7.31 vs 2.23 years (p < 0.05). DN (n= 97) had average YLL at 9.76 years followed by LN (n = 243) at 7.1 years. The average YLL (years) for primary GN were: FSGS (n=125), 2.52 years; MGN (n=106), 2.32; IgAN (n=164), 2.26; and MCD (n=74) 1.57.
Conclusion
GN causes premature mortality with secondary GN being associated with higher premature death than primary GN. DN and Lupus nephritis have the highest YLL. This study provides useful information on the impact of GN for prioritization of public health policies intervention.