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Abstract: PO1930

Hypertriglyceridemia-Related Lipid Profiles Affect Glomerulosclerosis in IgA Nephropathy

Session Information

Category: Pathology and Lab Medicine

  • 1600 Pathology and Lab Medicine

Authors

  • Choi, Wonjung, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, Daejeon, Korea (the Republic of)
  • Chang, Yoon-Kyung, Department of Internal Medicine, Daejeon St. Mary’s Hospital, College of Medicine, Daejeon, Korea (the Republic of)
Background

Dyslipidemia, is one of the common complications of renal failure.There are many clinical factors that affect IgAN prognosis or histopathology. However, there are only few studies that analysis focused on the histopathologic features between IgA nephropathy with hypertriglyceridemia and related lipid profiles. We evaluate histopathologic features in IgAN between HyperTG group compared to normal TG group

Methods

Study Design This study is a cross-sectional study of a multi-center cohort that underwent kidney biopsy at 8 university hospitals affiliated with the College of Medicine Catholic University between January 2015 and May 2020 were diagnosed with IgAN. A total of 480 patients were enrolled in final cohort. Patient were divided into 2 groups that group 1; <150mg/dL, group 2; ≥150mg/dL.
Statistical Analysis Logistic regression analyses were performed to estimate the odds ratios (ORs). To define high grade of global and segmental glomerulosclerosis ≥25% define as high grade glomerulosclerosis and <25% define as low grade glomerulosclerosis. Grades 2-4 of MME, MCP were defined as high grade.

Results

Association between serum TG and histopathologic parameters Multivariable linear regression analysis showed that the that percent of GS, SS and CA, MME, MCP scores were positively associated with TG levels.Table 4 shows that HyperTG group showed more higher risk for global and segmental sclerosis after adjusting clinical and labaratory variables.

Conclusion

In conclusion, HyperTG is associated with glomerular sclerosis and mesangial proliferation. Also, HyperTG is independently relevant risk factor for global and segmental sclerosis.

Table 3 Linear regression for TG and the histopathologic parameters

Table 4 Logistic regression for TG groups and histopathologic parameters