Abstract: PO0021
Association Between Inflammation Markers in Patients with SARS-Cov-2 with the Development and Severity of AKI
Session Information
- COVID-19: AKI and Basic Science
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Coronavirus (COVID-19)
- 000 Coronavirus (COVID-19)
Authors
- Delgado Astorga, Claudia, Hospital Civil de Guadalajara Dr Juan I Menchaca, Guadalajara, Jalisco, Mexico
- Nava-Vargas, Miriam Gabriela, Hospital Civil de Guadalajara Dr Juan I Menchaca, Guadalajara, Jalisco, Mexico
- Andrade-Sierra, Jorge, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco, Mexico
- Rojas-Campos, Enrique, Hospital de Especialidades del Centro Medico Nacional de Occidente IMSS, Guadalajara, Jalisco, Mexico
Background
Acute Kidney Injure (AKI) is a common complication associated with SARS-CoV2 infection. Sepsis, direct cellular injury due to the tropism of the virus, and systemic inflammation are mechanisms involved in its development.
Methods
Prospective Cohort from March-2020 to March-2021 including 200 patients ≥18 yrs with SARS CoV2 for RT-PCR. All patients with development of AKI (KDIGO classification) during their hospitalization were registered. Age, gender, hospitalization time, oxygen use, SOFA, APACHE II, BRESCIA, PAFI,Leukocytes, creatinine (CrS) andinflammation markers (procalcitonin, ferritin, RCP, LDH, D-dimer) were registered.
Results
The incidence of AKI was 40%, 77% were male, 64% had AKI 1 and 36% were AKIN 2 y 3. The use of higher supplemental oxygen, APACHE, BRESCIA, D-Dimer and procalcitonin at day 9 and 12 were associated with AKI. In a logistic regression analysis, risk factor to AKI was septic shock (RR; 1.7-117; p=0.013). Other results are shown in Table
Conclusion
Inflammatory markers (d-Dimer and procalcitonin) were associated with the development and severity of AKI but only septic shock was predictive of the development of AKI
Comparison of socio-demographic in patients with SARS CoV-2 and AKI
AKI=80 | No AKI=120 | p | |
Age (years) | 61 ± 15 | 55 ± 14 | NS |
Weight, (kg) | 87 ± 19 | 86 ± 21 | NS |
Hospitalization (days) | 7 ± 6.13 | 2 ± 2.0 | NS |
Oxigen used (L/min) | 2.4 ± 1.17* | 1.8 ± 1.0* | 0.001 |
APACHE II score | 12.7 ± 5.7 | 8.9 ± 6.0 | 0.001 |
SOFA score | 4 ± 3.0 | 3 ± 2.3 | NS |
Brescia-Covid score | 2.42 ± 1.05* | 1.93 ± 0.90* | 0.004 |
d-Dimer (ng/mL) | 2.92 ± 1.97* | 2.15 ± 1.6* | 0.007 |
Ferritin (ng/mL) | 830 ± 609 | 791 ± 480 | NS |
RCP (mg/dL) | 158 ± 112 | 152 ± 109 | NS |
Procalcitonin 9 Day 12 Day | 2.85 ± 5.3* 3.5 ± 5.3* | 0.9 ± 1.25* 0.50 ± 0.60* | 0.035 0.012 |
CrS (AKI 1) (mg/dL) CrS(AKI 2-3) (mg/dL) | 0.81 ± 0.40* 3.0 ± 2.0* |