Abstract: INFO06
The Kidney Precision Medicine Project (KPMP)
Session Information
- Informational Posters
November 04, 2021 | Location: On-Demand, Virtual Only
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- No subcategory defined
Authors
- Himmelfarb, Jonathan, University of Washington School of Medicine, Seattle, Washington, United States
- Kretzler, Matthias, University of Michigan Health System, Ann Arbor, Michigan, United States
- Iyengar, Ravi, Icahn School of Medicine at Mount Sinai, New York, New York, United States
Group or Team Name
- Kidney Precision Medicine Project (KPMP)
Description
The Kidney Precision Medicine Project (KPMP) is a National Institute of Diabetes and Digestive and Kidney Diseases funded consortium that aims to better understand and treat human kidney diseases. The goals of KPMP are to ethically and safely obtain kidney biopsies from participants with diagnosed acute kidney injury (AKI) or chronic kidney disease (CKD), to find disease subgroups to better stratify kidney disease patients, to identify critical cells pathways and targets for novel therapies, and to create a kidney tissue atlas.
Currently, 35 sites make up the consortium, including eight sites that serve as AKI or CKD recruitment & biopsy centers, and six multi-site tissue interrogation centers that analyze the biopsy tissues through a combination of imaging, transcriptomic, proteomic and metabolomic technologies. The KPMP Opportunity Pool has funded 18 projects to serve as key collaborators for the consortium. Coordination of study activities is led by several sites in a federated Central Hub. Central Hub responsibilities include administrative organization, data coordination, integration and visualization. Patient engagement is paramount to the work of the consortium; kidney patients advise on study activities by serving on the KPMP Community Engagement Committee, as well as other consortium committees, including the Steering Committee.
KPMP is a publicly available resource to both research and lay communities. The KPMP website www.kpmp.org is a gateway to access all study resources, including protocols and the kidney tissue atlas. Non-identifiable data for the 100+ biopsied participants are made available to the research community immediately after validation at www.atlas.kpmp.org. There are currently over 1500 datasets available to the research community. Funded collaboration opportunities are periodically available through RFAs on the study website. The consortium is now accepting ancillary study applications.
Recent consortium publications include Rationale and design of the Kidney Precision Medicine Project, Integrating Patient Priorities with Science by Community Engagement in the Kidney Precision Medicine Project, Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications, and A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project.
Funding
- KPMP Is supported by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).