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Abstract: FR-PO644

Lymphangiogenesis in Biopsy-Proven Lupus Nephritis

Session Information

Category: Glomerular Diseases

  • 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials

Authors

  • Yeom, Jihyun, Jeonbuk National University Hospital, Jeonju, Jeollabuk-do , Korea (the Republic of)
  • Kang, Kyung Pyo, Jeonbuk National University Hospital, Jeonju, Jeollabuk-do , Korea (the Republic of)
Background

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune complex deposits, inflammatory cell infiltrations in multiple organs, and approximately half of the patients affected kidneys. The histological class and degree of activity/chronicity affected the therapeutic plan and prognosis in lupus nephritis. Thus, we intend to elucidate the correlation between lymphangiogenesis and activity indices in LN patients.

Methods

This study was reviewed and approved by the Institutional Review Board of Jeonbuk National University Hospital (CUH- 2020-07-032-001). We reviewed medical records for the biopsy-proven lupus nephritis and immunohistochemistry for D2-40 was performed. D2-40 positive lymphatic vessels were counted in the whole cortex of biopsy specimens, and the density of lymphatics was determined by computer-assisted morphometric analysis (magnification x200).

Results

Table 1 shows the clinical characteristics of the patient in our study. All 6 patients were women, demonstrating a female predominance in lupus, and renal manifestation occurred firstly in 2 patients at the time of diagnosis of lupus. In addition, 4 patients were proliferative lupus nephritis and showed high ANA titer, lower C3 levels, and higher activity indices.
Figure 1 describes the correlation between the expression of D2-40 positive lymphatic vessels and lupus activity indices, and two factors have a positive correlation. (p value=0.0302)

Conclusion

Our study shows the higher the activity indices, the more the expression of lymphatic vessels in lupus nephritis, which may help set treatment target in the future.

Table 1. The clinical characteristics of the patient

Figure 1. The correlation between the expression of D2-40 lymphatic vessels and lupus activity indices