Abstract: SA-PO379
Circulating Follistatin-Like Protein-1 Levels Predicts the Risk of Cardiovascular Events and Death in Hemodialysis Patients
Session Information
- Hemodialysis and Frequent Dialysis: CV and Risk Prediction
November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 701 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Kim, Dae Kyu, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)
- Kang, Seok hui, Yeungnam University Medical Center, Daegu, Korea (the Republic of)
- Kim, Jin sug, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
- Kim, Yang gyun, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)
- Lee, Yu ho, CHA Bundang Medical Center, Seongnam, Korea (the Republic of)
- Lee, Dong-Young, Korea Veterans Health Service, Wonju, Korea (the Republic of)
- Moon, Ju young, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)
- Lee, Sangho, Kyung Hee University Hospital at Gangdong, Seoul, Korea (the Republic of)
- Jeong, Kyung hwan, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
- Hwang, Hyeon Seok, Kyung Hee University Medical Center, Seoul, Korea (the Republic of)
Background
Follistatin-like protein-1 (FSTL-1) is cardiokine which are involved in the induction of angiogenesis, stimulation of cardiomyocyte proliferation and improvement of endothelial function. However, the clinical significance of circulating FSTL-1 levels remains unclear in hemodialysis patients.
Methods
A total 376 HD patients from the K-cohort were prospectively enrolled from June 2016 to March 2020. Plasma FSTL-1 level, plasma concentration of biomarkers and echocardiographic findings at baseline were examined. The primary endpoint was defined as a composite of CV events and death.
Results
Plasma FSTL-1 level had positive correlation with circulating cardiac remodeling (matrix metalloproteinase-2) and inflammatory markers (TNF-α, MCP-1). In multivariate linear regression analysis, FSTL-1 level was negatively associated with left ventricular ejection fraction (β = −0.36; P = 0.011). The cumulative event rate of the composite of CV event and death was significantly greater in FSTL-1 tertile 3 (P = 0.037). FSTL-1 tertile 3 was also associated with an increased cumulative event rate of CV events (P = 0.048). In Cox regression analysis, FSTL-1 tertile 3 was associated with a 1.80-fold risk for the composite of CV events and death (95% confidence interval [CI], 1.06–3.08), and a 2.29-fold risk for CV events (95% CI, 1.15–4.54) after adjustment for multiple variables.
Conclusion
Plasma level of FSTL-1 levels were independently associated with left ventricular systolic dysfunction and higher circulating FSTL-1 levels independently predicted the composite of CV events in HD patients.