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Abstract: SA-PO306

Effect of Hemodialysis on Lamina Cribrosa of Optic Nerve Head Measured by Swept-Source Optical Coherence Tomography

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Author

  • Lee, Won June, Hanyang University, Seongdong-gu, Seoul, Korea (the Republic of)
Background

The eyes and kidneys have numerous common structural, developmental, and physiologic pathways, suggesting that eye and kidney disease may be interlinked. Hemodynamic changes due to hemodialysis (HD) may affect the blood flow to the eyes, which may influence many structures of the eye. In this study, we investigated the effect of HD on lamina cribrosa (LC) of optic nerve head (ONH) by swept-source optical coherence (SS-OCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD).

Methods

A prospective observational study was performed on 28 patients who underwent HD for ESKD. Detailed ophthalmologic examinations and SS-OCT were performed immediately before and after HD. The ONH parameters including the LC position, were measured using built-in software. Changes in ONH parameters before and after HD were statistically analyzed.

Results

The mean anterior LC depth (LCD) significantly decreased from 441.6 ± 139.8 μm before HD to 413.5 ± 141.7 μm after HD (P=0.001). Mean neural canal diameter and mean papillary vertical height did not show significant change after HD (P=0.841. P=0.574, respectively). Significant correlation was found between changes in LCD and changes in mean ocular perfusion pressure (rho=0.397, P=0.036).

Conclusion

We observed significant decrease in anterior LCD after HD. Our study suggest that HD can give influence on the ONH, especially in LC.

Funding

  • Government Support – Non-U.S.