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Abstract: FR-PO279

Cardiac Hypertrophy in Rodents With Polycystic Kidney Disease (PKD) Before the Onset of Hypertension

Session Information

Category: Genetic Diseases of the Kidneys

  • 1101 Genetic Diseases of the Kidneys: Cystic


  • Oto, Ozgur Akin, Istanbul Universitesi Istanbul Tip Fakultesi, Istanbul, Istanbul, Turkey
  • Atwood, Daniel, University of Colorado Health, Aurora, Colorado, United States
  • Chaudhary, Anjana, University of Colorado Health, Aurora, Colorado, United States
  • Edelstein, Charles L., University of Colorado Health, Aurora, Colorado, United States

The aim of the study was to determine whether there is cardiac hypertrophy (CH) before hypertension (HTN) in rodents and to further detail cardiac structure/ function in the heart in Pkd1RC/RC (RC) mice.


12wk old PCK rats, a Pkhd1 gene model, and 120d RC mice, a hypomorphic Pkd1 gene model, were studied. A noninvasive tail-cuff system was used to measure BP. A Vevo 2100 was used for Echocardiography/ mitral Doppler measurements


Heart weight/body weight (HW/BW) was increased in PCK rats at 12wks. HTN develops at 16wks in PCK rats. HW/BW was increased in RC mice before the onset of HTN (table). We previously described increased mTORC1/2/suppressed autophagy in the heart in 70d RC mice. mTORC1/ autophagy play a role in the CH, so we detailed cardiac structure/ function in RC mice. There was cardiac hypertrophy: increased intra-ventricular septum (IVS) and left ventricular wall (LVW) thickness. On echo there was increased LV mass, decreased ratio of peak velocity of early/ late filling of mitral inflow (grade 1 diastolic dysfunction) and decreased LV diastolic volume. Interestingly in 270dRC mice the cardiac dysfunction was different. There was severe Grade 4 diastolic dysfunction (increased E/A ratio) indicating restrictive filling of the LV. Normal ejection fraction fractional shortening indicated heart failure with preserved EF.


There was increased heart weight, CH, increased LV mass, grade 1 diastolic dysfunction, in RC mice before the onset of HTN. Factors other than HTN like increased mTORC1/2/ suppressed autophagy may contribute to causing CH in PKD mice.

 +/+PCK rat+/+ mouse (120d)RC mouse (120d) +/+ mouse (270d)RC mouse (270d)
HW/BW (%)0.310.35 *0.470.53***HW/BW (%)0.530.66 *
E/A ratio  1.51.2*E/A ratio1.11.4*
Syst/Diast Mean BP  116/88/97109/84/92   
IVS/LVW (um)  1045/9561286*/1218 **EF/FS (%)49/2558/30
LV mass (mg/g)  1.21.5*   
LV Diast vol (µL)  5771*   

*P<0.05, **P<0.01, ***P<0.001


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