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Abstract: FR-PO025

RECOVID: Renal Outcomes and Mortality in Patients With COVID-19 Infection at UCLA

Session Information

Category: Coronavirus (COVID-19)

  • 000 Coronavirus (COVID-19)

Authors

  • Fahim, Peter, University of California Los Angeles, Los Angeles, California, United States
  • Jang, Charley Qi Hua, University of California Los Angeles, Los Angeles, California, United States
  • Grogan, Tristan, University of California Los Angeles, Los Angeles, California, United States
  • Vasilyev, Arseniy, University of California Los Angeles, Los Angeles, California, United States
  • Kamgar, Mohammad, University of California Los Angeles, Los Angeles, California, United States
  • Nobakht, Niloofar, University of California Los Angeles, Los Angeles, California, United States
Background

Acute kidney injury (AKI) is a common complication in patients with COVID-19 infection with rates as high as 32% to 46% and has been associated with poor outcomes. Our study investigates the frequency, risk factors, need for kidney replacement therapy (KRT), and mortality among patients with COVID-19 infection and AKI in both vaccinated and unvaccinated populations.

Methods

This retrospective, observational study is a review of 2 years of data from early pandemic in March 2020 till March 2022. Data of patients aged ≥18 years with laboratory-confirmed COVID-19 admitted to UCLA Ronald Reagan Medical Center and UCLA Santa Monica Medical Center were analyzed.

Results

Among the 3527 hospitalized patients with COVID-19, AKI occurred in 972 (27.6%) patients. Of the 972 patients with AKI, 411 (42.3%) did not receive the COVID-19 vaccine, 94 (9.6%) were partially vaccinated (1 dose), and 465 (48.1%) were fully vaccinated patients (2 doses). Among AKI patients, in-hospital mortality was 46.2% in unvaccinated patients versus 12.4% in fully vaccinated (OR 6.1, 95% CI, 4.3 to 8.5) and 18% of unvaccinated patients remained on dialysis at discharge versus 12.2% among fully vaccinated (OR 1.6, 95% CI, 1.1 to 2.3).

Conclusion

Fully vaccinated patients with COVID-19 infection and AKI had less in-hospital mortality and were less dialysis-dependent at the time of discharge.