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Abstract: SA-PO384

Serum GDF-15/Albumin Ratio Is a Survival Marker of CKD Patients Initiating Maintenance Hemodialysis

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Ham, Youngrok, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
  • Lee, Eu Jin, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
  • Han, Soo hyun, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
  • Lee, Kang Wook, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
  • Na, Kiryang, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
  • Choi, Dae Eun, Chungnam National University Hospital, Daejeon, Korea (the Republic of)
Background

It is valuable to identify risk factors related to mortality in chronic kidney disease(CKD) patients starting renal replacement therapy. Recently, several studies proposed that growth-differentiation factor-15 (GDF-15) is a possible biomarker for the prognosis of patients on maintenance hemodialysis. Here, we investigated the predictive value of serum GDF-15/Albumin ratio on two-year mortality in ESRD patients initiating maintenance hemodialysis.

Methods

The study was a single center, retrospective study on CKD patients starting maintenance hemodialysis with a follow-up of two years. We reviewed the medical records of the patients who were diagnosed with CKD, naïve to renal replacement therapy and prescribed to start maintenance hemodialysis rom May 2014 to August 2019. 159 patients were eligible for analysisThe biospecimens and data used for further analysis on GDF-15 were provide by the Biobank of Chungnam National University Hospital, a member of the Korea Biobank Network.

Results

he patients were stratified into quartiles according to the quartiles of serum GDF-15/Albumin ratio. Among the 159 patients, the mean age was 61.78 ± 12.52 years and median survival was 20.03 ± 7.73 months. The highest GDF-15/Albumin quartile was significantly more associated with the increased risk of all-cause mortality than other quartiles (unadjusted hazard ratio (HR): 8.468, 95% CI 2.981–24.054, p < 0.001). Older age and a higher overhydration state were associated with GDF-15/Albumin ratio. The ROC analysis confirmed that the ability of the GDF-15/Albumin ratio to predict mortality was superior to GDF-15 or albumin alone.

Conclusion


the GDF-15/Albumin ratio measured at the initial maintenance hemodialysis is an independent prognostic marker of two-year mortality in CKD patients.

Funding

  • Government Support – Non-U.S.