ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Abstract: INFO12

NUGoKidney Research Cores: Paving the Way for Breakthroughs in Kidney Therapeutics

Session Information

  • Informational Posters
    November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category: Educational Research

  • No subcategory defined

Authors

  • Liz, Esmeralda, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Quaggin, Susan E., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Kapitsinou, Pinelopi P., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Description

The Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) unites investigators across three cores covering all aspects of the kidney therapeutic pipeline from basic discovery-based (Pre-Clinical Models Core [A]) to design and development of nephrotherapeutics including biologics, nanoparticles and cell-based reagents (Therapeutics Design and Development Core [B]) to design and execution of trials in patients (Clinical and Translational Core [C]). Core A offers researchers access to over 30 unique kidney disease models and cell-specific knockout lines, and services enabling generation of induced pluripotent stem cells from patients with kidney diseases. Core B brings together the expertise and cutting-edge techniques of Northwestern’s research infrastructure to support the development of bio-inspired nano-delivery systems, biological and small molecule therapeutics, and cell-based therapeutics for precision targeting kidney disease-specific pathogenesis. Development of ‘off-the-shelf’ nanoparticles to target specific renal cell types is a major goal of current activities. Core C connects investigators with clinical research services and resources, including clinical research coordinator support; analytic, clinical trial, patient-reported outcomes, and bioethics expertise; unique data and biosample repositories; and input from community-engaged researchers.

NUGoKIDNEY has Pilot and Feasibility and Enrichment Programs. The Pilot and Feasibility Program offers pilot grants to support cross-disciplinary translational research for the identification and development of new therapies for kidney disease. The Enrichment Program provides an array of education and outreach activities that (1) provide training and career development for next generation researchers and (2) share new knowledge with the scientific and lay communities. Notable activities include hosting an annual Kidney Disease Therapeutic Innovation Symposium; community-engaged partnership development to improve kidney health disparities on Chicago’s South Side; and a vibrant high school program – SciHigh – that prepares students from underrepresented communities for biomedical careers through summer mentorship, workshops, and classroom activities.

Funding

  • Funded by the National Institute of Diabetes and Digestive and Kidney Diseases, the Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) supports innovative research and cross-cutting collaborations between basic and clinical scientists to advance the discovery of novel therapeutics that will transform the prevention and treatment of kidney diseases.
Abstract: INFO12

NUGoKidney Research Cores: Paving the Way for Breakthroughs in Kidney Therapeutics

Session Information

  • Informational Posters
    November 04, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category:

  • No subcategory defined

Authors

  • Liz, Esmeralda, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Quaggin, Susan E., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Kapitsinou, Pinelopi P., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Description

The Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) unites investigators across three cores covering all aspects of the kidney therapeutic pipeline from basic discovery-based (Pre-Clinical Models Core [A]) to design and development of nephrotherapeutics including biologics, nanoparticles and cell-based reagents (Therapeutics Design and Development Core [B]) to design and execution of trials in patients (Clinical and Translational Core [C]). Core A offers researchers access to over 30 unique kidney disease models and cell-specific knockout lines, and services enabling generation of induced pluripotent stem cells from patients with kidney diseases. Core B brings together the expertise and cutting-edge techniques of Northwestern’s research infrastructure to support the development of bio-inspired nano-delivery systems, biological and small molecule therapeutics, and cell-based therapeutics for precision targeting kidney disease-specific pathogenesis. Development of ‘off-the-shelf’ nanoparticles to target specific renal cell types is a major goal of current activities. Core C connects investigators with clinical research services and resources, including clinical research coordinator support; analytic, clinical trial, patient-reported outcomes, and bioethics expertise; unique data and biosample repositories; and input from community-engaged researchers.

NUGoKIDNEY has Pilot and Feasibility and Enrichment Programs. The Pilot and Feasibility Program offers pilot grants to support cross-disciplinary translational research for the identification and development of new therapies for kidney disease. The Enrichment Program provides an array of education and outreach activities that (1) provide training and career development for next generation researchers and (2) share new knowledge with the scientific and lay communities. Notable activities include hosting an annual Kidney Disease Therapeutic Innovation Symposium; community-engaged partnership development to improve kidney health disparities on Chicago’s South Side; and a vibrant high school program – SciHigh – that prepares students from underrepresented communities for biomedical careers through summer mentorship, workshops, and classroom activities.

Abstract: INFO12

NUGoKidney Research Cores: Paving the Way for Breakthroughs in Kidney Therapeutics

Session Information

  • Informational Posters
    November 05, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
    Abstract Time: 10:00 AM - 12:00 PM

Category:

  • No subcategory defined

Authors

  • Liz, Esmeralda, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Quaggin, Susan E., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Kapitsinou, Pinelopi P., Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
  • Isakova, Tamara, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States
Description

The Northwestern University George M. O’Brien Kidney Research Core Center (NUGoKIDNEY) unites investigators across three cores covering all aspects of the kidney therapeutic pipeline from basic discovery-based (Pre-Clinical Models Core [A]) to design and development of nephrotherapeutics including biologics, nanoparticles and cell-based reagents (Therapeutics Design and Development Core [B]) to design and execution of trials in patients (Clinical and Translational Core [C]). Core A offers researchers access to over 30 unique kidney disease models and cell-specific knockout lines, and services enabling generation of induced pluripotent stem cells from patients with kidney diseases. Core B brings together the expertise and cutting-edge techniques of Northwestern’s research infrastructure to support the development of bio-inspired nano-delivery systems, biological and small molecule therapeutics, and cell-based therapeutics for precision targeting kidney disease-specific pathogenesis. Development of ‘off-the-shelf’ nanoparticles to target specific renal cell types is a major goal of current activities. Core C connects investigators with clinical research services and resources, including clinical research coordinator support; analytic, clinical trial, patient-reported outcomes, and bioethics expertise; unique data and biosample repositories; and input from community-engaged researchers.

NUGoKIDNEY has Pilot and Feasibility and Enrichment Programs. The Pilot and Feasibility Program offers pilot grants to support cross-disciplinary translational research for the identification and development of new therapies for kidney disease. The Enrichment Program provides an array of education and outreach activities that (1) provide training and career development for next generation researchers and (2) share new knowledge with the scientific and lay communities. Notable activities include hosting an annual Kidney Disease Therapeutic Innovation Symposium; community-engaged partnership development to improve kidney health disparities on Chicago’s South Side; and a vibrant high school program – SciHigh – that prepares students from underrepresented communities for biomedical careers through summer mentorship, workshops, and classroom activities.