Kidney Week

Abstract: TH-PO0167

Clinical Characteristics of ADPKD in Thailand

Session Information

• ADPKD and Cystic Kidney Disease - 1
  October 22, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Genetic Diseases of the Kidneys

• 1201 Genetic Diseases of the Kidneys: Cystic (Monogenic)

Authors

• Vareesangthip, Kornchanok, Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Kornchanok Vareesangthip, MD

• Chansamut, Nakit, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Nakit Chansamut, MD

• Rochaikun, Kitilak, Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Kitilak Rochaikun, MSc

• Vareesangthip, Kriengsak, Renal Division, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Kriengsak Vareesangthip, MD, PhD

Background

Autosomal dominant polycystic kidney disease (ADPKD) is a major inherited cause of kidney failure requiring kidney replacement therapy (KRT). Southeast Asian data, especially where disease-modifying therapy is inaccessible, are scarce. We evaluated factors associated with KRT in a Thai cohort.

Methods

We retrospectively studied ADPKD patients followed at Siriraj Hospital during 1969-2024. Cases were identified by ICD-10 code Q61.2 and confirmed by ultrasonographic criteria. Clinical, imaging, and outcome data were extracted from records. Because of financial barriers, no patients received tolvaptan. The outcome was KRT. Cox models identified KRT-associated factors.

Results

Among 988 patients, 471 (47.7%) were male. Median age at diagnosis was 48.4 years (IQR, 37.4–59.0), and median age at last follow-up was 58.4 years (IQR, 46.9–69.3). Incidental imaging diagnosis occurred in 48.5%, while CKD was the first presentation in 14.3%. Renal cyst complications occurred in 31.5%, and polycystic liver disease in 78.1% of patients with imaging. Overall, 269 patients (27.4%) developed KRT at a median age of 53.0 years (IQR, 45.5–61.5). Larger kidney length predicted higher KRT risk (aHR, 1.12 per cm; 95% CI, 1.08–1.16; p<0.001), whereas incidental diagnosis predicted lower risk (aHR, 0.52; 95% CI, 0.37–0.73; p<0.001).

Conclusion

In the largest Thai ADPKD cohort, kidney failure requiring KRT occurred in more than one-quarter of patients. This tolvaptan-naïve cohort provides Southeast Asian natural-history evidence and supports the need for a national registry for earlier diagnosis, risk stratification, monitoring, and evaluation of disease-modifying therapy.