Abstract: TH-PO0250
Value of 5.0T Multiparametric MRI in Assessment of Renal Fibrosis in Patients with CKD
Session Information
- CKD: Mechanisms of Injury and Fibrosis - 1
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2202 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Sun, Qian, Southeast University Zhongda Hospital, Nanjing, Jiangsu, China
- Wu, Min, Southeast University Zhongda Hospital, Nanjing, Jiangsu, China
Background
Renal fibrosis is the core pathological process in the progression of CKD. Exploring non-invasive evaluation methods for renal fibrosis is of great clinical significance. This study aimed to investigate the application value of 5.0T MRI in the assessment of renal fibrosis.
Methods
This study prospectively enrolled CKD patients in the Department of Nephrology, Zhongda Hospital from December 2024 to September 2025. The inclusion criteria were patients who were diagnosed with CKD; who had definite indications for renal biopsy; who voluntarily completed 5.0T MRI scanning. The exclusion criteria included patients with metal implants, claustrophobia, AKI; who refused renal biopsy; unqualified image quality. Meanwhile, healthy volunteers (HVs) were enrolled as the control group. All participants completed 5.0T MRI scanning, including ASL, IVIM and DTI sequences. Parameters of MRI, clinical and pathological data were collected to explore the correlation between 5.0T MRI parameters and renal fibrosis.
Results
A total of 70 participants, including 18 HVs and 52 CKD patients, were finally enrolled in our study. Significant intergroup differences were observed in cortical and medullary renal blood flow (cRBF and mRBF), cortical and medullary perfusion fractions (cf and mf), and medullary fractional anisotropy (mFA) between HVs and CKD patients (p < 0.05), with consistently lower values in the CKD group. The CKD patients were further stratified into three subgroups according to the area of renal fibrosis (RF0: <25%, n = 32; RF1: 25%-50%, n = 9; RF2: >50%, n = 11). With the aggravation of renal fibrosis across the three subgroups, cRBF, mRBF, mf and mFA exhibited a significant stepwise reduction. Correlation analysis revealed that cRBF, mRBF, mf and mFA were negatively correlated with the area of renal fibrosis (p < 0.05), among which mFA (r = -0.56) and cRBF (r = -0.51) showed the strongest correlation (p < 0.001). Linear regression analyses confirmed that cRBF (β = -0.117) and mFA (β = -0.104) were independent predictive factors for area of renal fibrosis.
Conclusion
Multiple functional parameters derived from 5.0T MRI were significantly correlated with the area of renal fibrosis. Among these parameters, cRBF and mFA were identified as independent predictive factors. These findings suggest the potential of 5.0T multiparametric MRI in the non-invasive evaluation of renal fibrosis in CKD patients.