Basic/Clinical Science Session
From Acute Injury to Chronic Dysfunction: Genomic Drivers of Kidney Allograft Longevity
October 24, 2026 | 02:00 PM - 04:00 PM
Location: Room 401, Convention Center
Session Description
Progressive kidney allograft dysfunction and graft loss remain major challenges in kidney transplantation. Emerging evidence implicates non-human leukocyte antigen (HLA) genetic variants and donor-recipient genomic mismatches as drivers of injury and fibrosis. Advances in single-cell and spatial multi-omics technologies provide cell-resolved insights into injury responses, molecular checkpoints of repair, and the transition from acute injury to CKD. This session highlights innovative mechanisms, noninvasive biomarkers, and targeted strategies to improve long-term graft survival.
Learning Objective(s)
- Explain how non-HLA genetic variants and donor-recipient genomic mismatches contribute to progressive kidney allograft injury, fibrosis, and long-term graft loss
- Describe emerging single-cell and spatial multi-omics data to distinguish adaptive repair from maladaptive remodeling pathways in kidney allografts
- Evaluate novel diagnostic and noninvasive monitoring strategies for early detection and risk stratification of progressive allograft dysfunction
- Discuss cell-specific and genomic insights into targeted therapeutic strategies to improve long-term kidney allograft survival and patient outcomes
Learning Pathway(s)
- Kidney Transplantation
- Genetic Diseases and Development
Moderators
Presentations
- Genetic Determinants of Graft Injury: Donor Identity Meets Recipient Biology
02:00 PM - 02:30 PM
- Epithelial Immune Checkpoints in Kidney Graft Injury and Repair
02:30 PM - 03:00 PM
- Time-Dependent Roles of Alarmin-Treg-Epidermal Growth Factor Receptor Axis in Adaptive vs. Maladaptive Repair
03:00 PM - 03:30 PM
- Cell-Specific Urinary Exosomal mRNAs for Monitoring Kidney Allograft Injury and Progression
03:30 PM - 04:00 PM