Basic/Clinical Science Session
Translating Proximal Tubule Transport Physiology to Therapy
October 23, 2026 | 02:00 PM - 04:00 PM
Location: Mile High Ballroom 1D, Convention Center
Session Description
This session explores how advances in kidney transport physiology have driven progress in nephrology. Experts review proximal tubule transport mechanisms, including strategies to target sodium handling to overcome diuretic resistance, insights into glucose transport and uremic toxin formation, calcium vs. magnesium absorption via claudins and its link to nephrocalcinosis, and emerging evidence on proximal tubule sulfate transport in musculoskeletal disease.
Learning Objective(s)
- Define the role of proximal tubule sodium handling in diuretic resistance
- Discuss novel insights into proximal tubule metabolic communication
- Describe the role of preferential paracellular calcium over magnesium transport in preventing nephrocalcinosis
- Summarize the role of proximal tubule sulfate transport and the development of musculoskeletal disease
Learning Pathway(s)
- Kidney Biology and Physiology
- Genetic Diseases and Development
Moderators
Presentations
- Metabolic Communication of the Proximal Tubules
02:00 PM - 02:20 PM
- Sodium Transport in Proximal Tubules and Diuretic Resistance
02:20 PM - 02:40 PM
- Sulfate Reabsorption in Proximal Tubules and Musculoskeletal Health
02:40 PM - 03:00 PM
- Proteinuria and the Proximal Tubules
03:00 PM - 03:20 PM
- Role of Proximal Tubule Claudins in Nephrocalcinosis
03:20 PM - 03:40 PM
- Q&A
03:40 PM - 04:00 PM