Basic/Clinical Science Session
Genetics and Multi-Omics in Diabetic Kidney Disease: From Risk Loci to Cell Type-Specific Mechanisms
October 24, 2026 | 02:00 PM - 04:00 PM
Location: Four Seasons Ballroom 1, Convention Center
Session Description
Human genetics has transformed the understanding of diabetic kidney disease (DKD) by identifying risk loci that implicate specific biological pathways and cell types. This session integrates insights from genome-wide association studies, rare-variant analyses, and multi-omics profiling to connect genetic risk with molecular mechanisms in kidney tissue. Experts discuss how integrating genetics with transcriptomics, proteomics, and splicing data defines DKD subtypes, informs disease trajectories, and enables genetics-driven biomarker development.
Learning Objective(s)
- Summarize the genetic architecture of DKD and its implications for causal pathway identification
- Describe how integration of genetics with multi-omics data defines molecular subtypes and progression mechanisms in DKD
- Explain how protein and splicing quantitative trait loci (QTLs) link genetic variation to cell type-specific effector mechanisms
Learning Pathway(s)
- Cardiovascular-Kidney-Metabolic (CKM) Health
- Genetic Diseases and Development
Moderators
Presentations
- Genetic Architecture of DKD: Discovery of Common and Rare Variants
02:00 PM - 02:30 PM
- Integrating DKD Genetics with Kidney Precision Medicine Project (KPMP) Multi-Omics Data to Define Molecular Subtypes
02:30 PM - 03:00 PM
- Functional Interpretation of DKD Risk Loci Through Protein QTLs or Splicing QTLs
03:00 PM - 03:30 PM
- Genetics- and Proteomics-Informed Biomarkers in DKD: Emphasis on Risk Prediction
03:30 PM - 04:00 PM