To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.
CLINICAL TRIAL DOES NOT SUPPORT THE USE OF BORTEZOMIB FOR KIDNEY TRANSPLANT RECIPIENTS • In a trial of kidney transplant recipients with late antibody-mediated rejection, treatment with bortezomib, a type of proteasome inhibitor, failed to improve the function of transplanted kidneys and prevent immunologic tissue injury.
• Bortezomib treatment was also linked with gastrointestinal and hematologic toxicity.
Thursday, December 14, 2017
SURVIVAL RATES ARE IMPROVING FOR INDIVIDUALS WITH KIDNEY FAILURE • In the United States, the excess risk of kidney failure–related death decreased by 12% to 27% over any 5-year interval between 1995 and 2013.
• Decreases in excess mortality over time were observed for all ages and both during treatment with dialysis and during time with a functioning kidney transplant.
Thursday, December 14, 2017
STUDY PROVIDES INSIGHTS ON IMMUNE CELLS INVOLVED IN KIDNEY DISEASE • New research indicates that the role of dendritic cells in kidney inflammation is more complex than previously thought. Different types of dendritic cells communicate with each other to control the magnitude of the immune response.
• The findings may lead to a better understanding of various types of kidney disease.
Thursday, December 7, 2017
STUDY IDENTIFIES GENES INVOLVED IN TOLERANCE FOLLOWING KIDNEY TRANSPLANTATION • In tissue samples from patients who received kidney transplants without the need for chronic immunosuppression, researchers found increased expression of many genes associated with the regulation of certain immune cells.
• The findings provide an improved understanding of transplant organ acceptance and rejection.
Thursday, November 30, 2017
VA PATIENTS FACE DISPARITIES IN KIDNEY TRANSPLANTATION From 2004 to 2016, VA patients had lower rates of transplantation compared with patients with Medicare or private insurance.
VA patients also had a higher rate of mortality on the waiting list compared with privately insured patients.
Saturday, November 4, 2017
MARK D. OKUSA ELECTED PRESIDENT OF THE AMERICAN SOCIETY OF NEPHROLOGY The American Society of Nephrology (ASN), the world's largest organization of kidney health professionals, has elected Mark D. Okusa, MD, FASN, as the next ASN President.
Dr. Okusa officially assumes his role as ASN President during the society's annual meeting, ASN Kidney Week 2017, the largest gathering of kidney care specialists in the world, and will begin his term on January 1, 2018
Saturday, November 4, 2017
RESEARCHERS IDENTIFY POTENTIAL AUTOANTIGEN IN AGGRESSIVE FORM OF KIDNEY DISEASE • A particular protein is found in abundance in the kidneys of patients with an aggressive form of kidney disease called fibrillary glomerulonephritis. The discovery may improve diagnosis, and eventually, treatment.
• The protein was identified by two research groups, working independently.
Thursday, November 2, 2017
THE AMERICAN SOCIETY OF NEPHROLOGY HONORS LEADERS IN THE FIGHT AGAINST KIDNEY DISEASES • Five leaders in the kidney health community are being honored by the American Society of Nephrology (ASN), the world's largest organization of kidney disease specialists.
• The award winners will be honored at ASN Kidney Week, the world's premier nephrology meeting where more than 13,000 kidney health professionals from around the world will gather in New Orleans, LA from October 31–November 5.
Monday, October 30, 2017
KIDNEY TRANSPLANTATION MAY PROLONG THE SURVIVAL OF PATIENTS ON LONG-TERM DIALYSIS • In a recent analysis of individuals on dialysis for at least 10 years, those who then received a kidney transplant lived longer than those who stayed on dialysis.
• Transplant recipients were at higher risk of death for 180 days after transplantation, however, and they did not derive survival benefit until 657 days after transplantation.
Thursday, October 26, 2017
ASN AND KERYX BIOPHARMACEUTICALS TEAM UP TO FUND KIDNEY CAREER DEVELOPMENT GRANT • Keryx Biopharmaceuticals, Inc. has committed to contributing $1 million over five years to the ASN Foundation for Kidney Research Securing the Future Campaign
• ASN has matched the donation to endow a Career Development Grant named for Joseph V. Bonventre, MD, PhD, FASN, Chief of the Division of Renal Medicine at Brigham and Women's Hospital in Boston, MA
Tuesday, October 24, 2017
GEORGE WASHINGTON UNIVERSITY REPORT FINDS IMPROVING JOB OUTLOOK FOR NEW NEPHROLOGISTS The American Society of Nephrology (ASN), the world's largest organization of kidney
health professionals, released a new analysis of the future nephrology workforce,
authored by George Washington University (GW) researchers.
• GW details an improved job market for new nephrologists, although international medical
graduates still face employment challenges. The report noted that lifestyle concerns are
important to fellows and may be discouraging applicants to the specialty.
More than 40 million Americans have kidney diseases, the 9th leading cause of death in the U.S. Monday, October 23, 2017
STUDY REVEALS HIGH HEALTHCARE COSTS LINKED WITH ACUTE KIDNEY INJURY • In a study of hospitalized patients in Canada, the mildest forms of acute kidney injury (AKI) resulted in adjusted costs that were 1.2 to 1.3 times greater than those for patients without AKI.
• More severe AKI were associated with costs that were 1.8 to 2.5 times greater.
• The incremental cost of AKI in Canada was estimated to be more than $200 million (Canadian dollars) per year.
Thursday, October 19, 2017
KIDNEY FAILURE'S EFFECTS ON THE PSYCHOSOCIAL HEALTH AND LIFESTYLE OF YOUNG ADULTS • Compared with healthy peers, young adults with kidney failure needing renal replacement therapy had lower quality of life, worse for dialysis patients compared with transplant patients.
• Young adults on renal replacement therapy were more likely to be unemployed and to live in the family home, and they were less likely to be married or have a partner.
Thursday, October 19, 2017
FEW PATIENTS HOSPITALIZED WITH ACUTE KIDNEY INJURY RECEIVE RECOMMENDED FOLLOW-UP CARE Most surveyed Canadian kidney specialists recommended follow-up kidney evaluations for the majority of patients hospitalized with acute kidney injury.
• Real-world practice showed that only a minority of such patients in Alberta currently receive follow-up with a kidney specialist.
Approximately 500 of every 100,000 adults are hospitalized with acute kidney injury each year in North America.
Thursday, October 19, 2017
STUDY OFFERS INSIGHTS ON HOW TO DECREASE THE DISCARD RATE OF DONATED ORGANS From 2008-2015, the number of kidneys donated after circulatory death that were obtained by the country's 58 donor service areas varied substantially.
The outcomes associated with these organs were generally excellent.
The use of these organs could be increased if "cold ischemia times" are limited. Thursday, October 5, 2017
WHY ARE MANY DIALYSIS PATIENTS READMITTED TO THE HOSPITAL SOON AFTER DISCHARGE? Among hemodialysis patients admitted to the hospital, nearly a quarter of admissions were followed by an unplanned readmission within 30 days.
Most readmissions were for a diagnosis different than the one for the initial
A small proportion of patients accounted for a disproportionate number of readmissions.
Thursday, September 28, 2017
STUDY REVEALS HIGH RATES OF OPIOID PRESCRIPTIONS AND EXCESSIVE DOSING IN DIALYSIS PATIENTS From 2006 to 2010, almost two thirds of US dialysis patients received at least one opioid prescription every year and >20% received chronic prescriptions.
More than 25% of dialysis patients using opioids received doses exceeding recommendations
Use of opioid medications was linked with higher risks of early death, discontinuation of dialysis, and the need for hospitalization in dialysis patients.
In 2016, the Centers for Disease Control and Prevention released a clinical guideline for prescribing opioids for chronic pain. Thursday, September 21, 2017
AIR POLLUTION MAY HAVE DAMAGING EFFECTS ON THE KIDNEYS In a study of US veterans, researchers found a linear relationship between air pollution levels and risk of experiencing kidney function decline and of developing kidney disease or kidney failure.
Air quality remains suboptimal in many parts of the United States and in multiple regions around the world.
Thursday, September 21, 2017
IMPAIRED SLEEP MAY HAVE SERIOUS HEALTH CONSEQUENCES FOR KIDNEY DISEASE PATIENTS • In individuals with chronic kidney disease, high sleep fragmentation was associated with an elevated risk of developing kidney failure.
• Higher sleep fragmentation and shorter sleep duration were each linked with steeper declines in kidney function over time.
• Subjectively measured daytime sleepiness was associated with an increased risk of early death from any cause.
Thursday, September 14, 2017
HCV TREATMENT FOUND SAFE AND EFFECTIVE IN INDIVIDUALS WITH KIDNEY DISEASE • In patients with chronic kidney disease and Hepatitis C virus infection, sofosbuvir-based direct-acting antiviral therapy was safe and effective.
• Patients with stage 3 kidney disease who were cured of infection experienced an improvement in their kidney function following treatment.
Thursday, September 7, 2017
NEW FINDINGS MAY HELP PROTECT THE KIDNEY HEALTH OF INDIVIDUALS WITH OBESITY • A particular receptor in kidney cells plays an important role in obesity-induced fat accumulation, dysfunction, injury, inflammation, and scarring in the kidney.
• The receptor acts through a certain signaling pathway.
• Targeting this receptor or the signaling pathway may help protect the kidneys of individuals who develop obesity.
Structural and functional changes in the kidneys develop early in the course of obesity.
Thursday, August 31, 2017
ASN Supports Hurricane Harvey Kidney Patient Relief Efforts As Houston area residents fight to survive Hurricane Harvey's flood waters and wreckage, the American Society of Nephrology (ASN) joins efforts by the American Kidney Fund (AKF) and the Kidney Community Emergency Response (KCER) coalition to provide continuity of care for displaced kidney dialysis patients in need of treatment.
Tuesday, August 29, 2017
STUDY EXAMINES WHETHER MARIJUANA AFFECTS KIDNEY FUNCTION In a recent study of healthy young adults, marijuana use was not associated with change in kidney function over time or the appearance of albumin in the urine, which is a sign of kidney damage.
Additional studies are needed to assess the effects of marijuana in older adults and patients with kidney disease.
Thursday, August 24, 2017
WHAT'S THE BEST STRATEGY TO INCREASE LIVING KIDNEY DONATION? There are very few high quality studies on strategies to increase living kidney donation.
From the limited data available, educational interventions directed at potential recipients and their social networks are the most promising.
Thursday, August 17, 2017
ATRIAL FIBRILLATION RISK RISES WITH DECREASING KIDNEY FUNCTION Investigators observed a step-wise increase in the risk of atrial fibrillation with decreasing kidney function. Compared with patients without kidney disease, those with severe kidney disease had a two-fold higher risk for developing atrial fibrillation..
This link held even after accounting for a range of possible contributors, including measures of cardiovascular health, and it was consistent across subgroups of participants.
The prevalence of atrial fibrillation has increased over time among patients with kidney failure.
Thursday, August 10, 2017
SMELL LOSS MAY CONTRIBUTE TO MALNUTRITION IN INDIVIDUALS WITH KIDNEY DISEASE A new study indicates that many patients with chronic kidney disease (CKD) have some degree of smell loss, and that impairments in patients’ ability to smell are linked with worse nutritional status. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), are significant because malnutrition is a well-known complication of CKD, and it can contribute to poor quality of life, poor overall health, and even premature death. Thursday, August 3, 2017
US TRANSPLANT CENTERS FREQUENTLY REFUSE DECEASED DONOR KIDNEYS From 2007-2012, deceased donor kidneys in the United States were offered a median of 7 times before finally being accepted for transplantation.
• Such refusals may have contributed to racial and ethnic disparities that exist in access to transplantation in the United States.
More than 100,000 people are on the kidney transplant waiting list in the United States. Thursday, July 27, 2017
DETAILED ANALYSIS OF DONOR-RECIPIENT TISSUE MISMATCH MAY HELP PERSONALIZE TREATMENT AFTER TRANSPLANTATION Researchers have found that a detailed examination of the degree of tissue type mismatch between donors and recipients can help determine how much medication an individual recipient will need after transplantation. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), may help guide transplant physicians in choosing the appropriate doses for individual patients. Thursday, July 20, 2017
STUDY PROVIDES INSIGHTS ON PREECLAMPSIA A new study indicates that patients discharged from the emergency department with acute kidney injury (AKI) remain at an increased risk of dying within 30 days. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). Thursday, July 20, 2017
BIOPSY TESTS MAY LEAD TO INAPPROPRIATE DISCARDS OF DONATED KIDNEYS Kidney biopsy results had no impact on the function of kidneys transplanted from living donors.
Outcomes following kidney transplantation using deceased donor kidneys were influenced by biopsy findings; however, even transplantation with kidneys with the worst biopsy findings would result in 5 additional years of life for a patient compared with remaining on dialysis.
Most deceased donor kidneys with suboptimal biopsy results were still functioning 5 years after transplantation
Thursday, July 6, 2017
AMERICAN SOCIETY OF NEPHROLOGY FOUNDATION FOR KIDNEY RESEARCH ANNOUNCES 2017 GRANT RECIPIENTS • The ASN Foundation for Kidney Research announced the 2017 recipients of research grants to advance new understandings of—and treatments for—kidney diseases.
• The Foundation will fund 40 leading researchers working to cure kidney diseases. These include 20 new projects and 20 others continuing from 2016.
• Established in 2012 by the American Society of Nephrology, the Foundation funds research that improves the health of the more than 20 million Americans burdened by kidney diseases, the ninth leading cause of death in the United States.
Thursday, July 6, 2017
CATHETERS LINKED TO MOST BLOODSTREAM INFECTIONS IN DIALYSIS PATIENTS Most bloodstream infections in dialysis patients continue to occur in those with central venous catheters used to access their blood. The findings come from 2014 data from US dialysis facilities.
Staphylococcus aureus was the most commonly isolated pathogen that caused bloodstream infections, and in many cases they were antibiotic-resistant.
Thursday, June 29, 2017
INTENSIVE BLOOD PRESSURE LOWERING BENEFITS PATIENTS WITH CHRONIC KIDNEY DISEASE In individuals with chronic kidney disease, targeting a systolic blood pressure to <120 mm Hg resulted in lower risks of cardiovascular events and premature death, compared with standard targeting to <140 mm Hg.
There was a slightly faster decline in kidney function in the intensive group, but no increase in rates of kidney failure or serious adverse events.
Washington, DC (June 22, 2017) — Results from a recent clinical trial indicate that intensive blood pressure lowering reduces chronic kidney disease (CKD) patients’ risks of Thursday, June 22, 2017
KIDNEYS FROM DIABETIC DONORS MAY BENEFIT MANY TRANSPLANT CANDIDATES Patients who received kidney transplants from donors with diabetes had better survival compared with those who remained on the waitlist.
Patients at high risk of dying while on the waitlist and those at centers with long wait times may benefit the most from transplantation with kidneys from diabetic donors.
Thursday, May 25, 2017
STUDY QUANTIFIES KIDNEY FAILURE RISK IN LIVING KIDNEY DONORS Researchers have developed a risk calculator that estimates the risk of kidney failure after donation.
Overall risk was quite low, but black race and male sex were associated with increased risks of developing kidney failure in living kidney donors.
Older age was associated with greater kidney failure risk in nonblack donors, but not in in black donors.
Higher body mass index and a close biological relationship to the transplant recipient were also associated with increased risks of kidney failure.
Thursday, April 27, 2017
HOSPITAL ACQUIRED COMPLICATIONS MAY BE ESPECIALLY DANGEROUS FOR PATIENTS WITH KIDNEY DISEASE Potentially preventable hospital acquired complications were associated with increased risks of dying while hospitalized or within 90 days of discharge, as well as with a greater likelihood of staying longer in the hospital and needing to be readmitted.
The magnitude of these associations was larger in patients with chronic kidney disease than in those with normal kidney function.
Thursday, April 27, 2017
STUDY EVALUATES HOW WELL FELLOWSHIP TRAINING PREPARES KIDNEY SPECIALISTS Most nephrology fellows rated overall quality of teaching in fellowships as either “good” or “excellent,” and over half of second-year fellows felt “fully prepared” for independent practice.
Fellows indicated a desire for more education in several core nephrology topics, including peritoneal dialysis and home hemodialysis, ultrasound, and kidney pathology.
Thursday, April 20, 2017
KIDNEY DISEASE IS A MAJOR CAUSE OF CARDIOVASCULAR DEATHS In 2013, reduced kidney function was associated with 4% of deaths worldwide, or 2.2 million deaths.
More than half of these deaths were cardiovascular deaths.
Maintaining kidney health may help prevent cardiovascular diseases and deaths.
Thursday, April 13, 2017
ARE DIALYSIS PATIENTS BEING OVER-SCREENED FOR COLON CANCER? Colonoscopies are being performed more often on healthier dialysis patients than on those with more limited life expectancies; however, overall, dialysis patients are being screened at a much higher rate relative to their life expectancy than their counterparts without kidney failure. Thursday, March 23, 2017
SICKLE CELL GENE LINKED TO ELEVATED RISK OF DEVELOPING KIDNEY FAILURE Sickle cell trait, a common hemoglobin variant in African Americans, was associated with a twofold higher risk of developing kidney failure requiring dialysis.
Sickle cell trait conferred a similar degree of risk as APOL1 gene variants, which are currently the most widely recognized genetic contributors to kidney disease in blacks.
Sickle cell trait, the inheritance of a single abnormal sickle hemoglobin gene, is found in 8-9% of African Americans. Thursday, March 9, 2017
HIV+ KIDNEY FAILURE PATIENTS FACE HURDLES IN RECEIVING NECESSARY TRANSPLANTS Efforts are needed to understand disparities in access to transplantation among HIV+ waitlist candidates
From 2001 to 2012, HIV+ kidney failure patients on the transplant waiting list were 28% less likely to receive a transplant compared with their HIV- counterparts.
They were half as likely to receive a kidney from a living donor.
More than 30% of HIV+ individuals in the United States have kidney disease, which can progress to kidney failure.
Thursday, February 23, 2017
LANGUAGE BARRIERS MAY INTERFERE WITH ACCESS TO KIDNEY TRANSPLANTATION English language fluency may be an important predictor of patients’ status on the transplant waiting list
Higher degrees of linguistic isolation were linked with a lower likelihood of transitioning from inactive to active status on the kidney transplant waiting list and with incomplete transplant evaluations.
The association of linguistic isolation appeared to be most influential among Hispanic transplant candidates.
Of the >100,000 candidates on the kidney transplant waiting list in the United States, approximately 30% are in “inactive” status.
Thursday, February 9, 2017
LOW LEVELS OF CIRCULATING PROTEIN LINKED TO KIDNEY FUNCTION DECLINE Findings suggest potential treatment strategy to protect kidney health
Decreased blood levels of a protein called soluble klothos were linked with an increased likelihood of experiencing kidney function decline in a group elderly well-functioning adults.
Thursday, January 19, 2017
TRIAL FINDS ORAL IRON DRUG SAFE AND EFFECTIVE FOR TREATING ANEMIA IN KIDNEY DISEASE PATIENTS In a phase 3 trial of patients with chronic kidney disease, 52.1% of patients receiving oral ferric citrate experienced a significant boost in hemoglobin levels (a reflection of red blood cell counts) compared with 19.1% of patients receiving placebo.
A treatment effect was seen as early as 1-2 weeks after the start of treatment, and the response was durable.
Thursday, January 12, 2017
MANY KIDNEY FAILURE PATIENTS LACK ADVANCE DIRECTIVES NEAR THE END OF LIFE Among nursing home residents in the last year of life, patients with kidney failure were far less likely to have advance directives that put limitations on treatments and designated surrogate decision makers compared with other nursing home residents with serious illnesses.
Advance directives with these components were associated with a lower use of intensive interventions at the end of life.
Nearly all kidney failure patients with an advance directive putting limitations on treatment received end-of-life care that was concordant with their preferences.
Thursday, January 5, 2017
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