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Abstract: FR-PO481

Hemoperfusion Associated with Impairment in Hemostasis in Patients with Acute Pesticide Intoxication

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Park, Samel, Soonchynhyang University, Cheonan, Korea, Cheonan, Korea (the Republic of)
  • Lee, Eun-Young, Soonchynhyang University, Cheonan, Korea, Cheonan, Korea (the Republic of)
Background

Hemoperfusion is one of the important treatment modalities in extracorporeal therapy for patients with acute intoxication. Its use has declined during the past 20 years despite its efficacy due to bleeding.

Methods

Twenty-five patients who underwent hemoperfusion due to acute pesticide intoxication participated. The changes in CBC, platelet function, platelet shape by SEM, platelet glycoprotein expression by FACS, and coagulation profiles were evaluated.

Results

After initiation HP, platelet count decreased by 40%. Delayed closure time that represents platelet dysfunction was observed; however, SEM showed activated shape-changed platelets adhered to activated charcoal. Platelet expressing CD61 (fibrinogen receptor) significantly decreased, while those expressing CD42b (vWF receptor) did not show significant change; however, platelet expressing CD49b (collagen receptor) significantly increased. Thrombin-antithrombin complex (a marker for thrombin generation) appeared to decrease without significance. FDP and d-dimers (markers for fibrinolysis) increased significantly during HP.

Conclusion

Our data suggest that hemoperfusion leads to increased platelet adhesion with decreased platelet aggregation, which might be associated with reduced thrombin generation and increased fibrinolysis.

Funding

  • Government Support - Non-U.S.