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Abstract: SA-PO538

Effects of Tubulointerstitial Plasmocyte Infiltration on Hard Clinical Renal Outcomes in Subjects with Diabetic Kidney Disease

Session Information

Category: Diabetic Kidney Disease

  • 602 Diabetic Kidney Disease: Clinical

Author

  • Zhang, Junlin, West China Hospital of Sichuan University, Chengdu, China
Background

Identification of the tubulointerstitial inflammatory features has the potential to the prediction of renal prognosis of diabetic kidney disease (DKD); however, the influence of plasmocyte infiltration on the DKD is unclear. This study was conducted to determine the association between the tubulointerstitial plasmocyte infiltration and DKD in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM).

Methods

We enrolled 226 adult patients with biopsy-proven DKD for a follow-up time more than 12 months. Tubulointerstitial plasma cells in kidney biopsy tissues were detected by immunohistochemistry and immunofluorescence. The patients then were divided into two groups based on tubulointerstitial plasmocyte infiltration: plasmocyte group (n=117) and non-plasmocyte group (n=109). Hard renal outcome was defined as end stage renal disease (ESRD). A comparison of the baseline features and renal prognosis between the two groups was performed.

Results

The accumulation of tubulointerstitial plasma cells was found to be related with more serious anemia, heavy proteinuria, renal function decline, and more serious glomerular, interstitial and arterial lesions. During the follow up (12-85 months), 42.5% (96) of patients developed ESRD. Patients in plasmocyte group exhibited a high percentage of incident ESRD (53%) than those (31.2%) in non-plasmocyte group (p<0.05). A Cox regression showed that the plasmocyte infiltration had a significant effect on the renal endpoint (HR, 1.969; 95%CI, 1.292-3.000), though it was not an independent risk factor.

Conclusion

As one of contributors to the renal inflammatory response, the tubulointerstitial infiltration of plasmocyte was associated with severity of glomerular, interstitial, and arterial lesions as well as DKD hard clinical renal outcome.

Funding

  • Government Support - Non-U.S.