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Abstract: FR-PO152

Low-Protein Rice Plus Low-Phosphorus Whey Improve Hyperphosphatemia in Hemodialysis Patients

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Authors

  • Wang, Song, Peking University Third Hospital, Beijing, China
  • Tian, Xinkui, Peking University Third Hospital, Beijing, China
Background

Hyperphosphatemia is common in end stage renal disease patients. Although adequate dialysis, dietary restriction, and phosphorus binders are prescribed, phosphorus control is still poor in dialysis patients.

Methods

Hemodialysis patients who had average serum phosphorus ≥5.5 mg/dl for consecutive three months were enrolled in this self-controlled trial. First, the patients received low phosphorus diet instruction. Then the patients received low protein rice plus low phosphorus whey for ten weeks. The protein gap between low protein rice and normal rice was replaced by low phosphorus whey. Finally the patients returned to normal rice for eight weeks. The changes of serum phosphorus, calcium, intact parathyroid hormone (iPTH) , serum albumin and nutritional evaluation were observed and analyzed.

Results

29 patients were enrolled. Serum phosphorus at baseline was (6.66±0.87) mg/dl. After four weeks diet instruction, serum phosphorus decreased to (6.27±1.54) mg/dl but with no significance (p>0.05). Serum phosphorus further decreased to (5.43±1.71) mg/dl, (5.36±1.50) mg/dl, (5.79±1.35) mg/dl respectively after changed to low protein rice for 2, 6 and 10 weeks (p<0.05 compared to the baseline). Serum phosphorus increased to(6.05±0.98) mg/dl after returned to normal rice. Dietary analysis showed the phosphorus intake was significantly low for low protein rice compare to normal rice (p<0.05). Besides, serum albumin increased significantly with low protein rice plus low phosphorus whey (p<0.05). There was no change in serum calcium, iPTH levels, dialysis strategy and phosphorus-binding agents throughout the study.

Conclusion

For hemodialysis patients who consume rice as their main source of calories, low protein rice plus low phosphorus whey can reduce serum phosphorus and improve serum albumin.

Serum phosphorus, calcium, intact parathyroid hormone and albumin changes during food intervention
 baseline2w6w
10w
18w
P(mg/dl)
6.66±0.875.43±1.71 *5.36±1.50 *5.79±1.35 *6.05±0.98 *
iPTH (pg/ml)
358.78±291.75  350.90±356.94367.24±309.76
ALB(g/dl)

3.98±0.32  4.23±0.35 *4.15±0.32 *

Values are expressed as mean ± standard deviation. *, Compared withbaseline, p<0.05

Funding

  • Commercial Support