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Abstract: FR-PO1097

Urinary Klotho Abnormalities in Pediatric Sickle Cell Disease (SCD)

Session Information

Category: Pediatric Nephrology

  • 1700 Pediatric Nephrology


  • Master sankar raj, Vimal, UICOMP, Peoria, Illinois, United States
  • Warnecke, Diana Lee, Univ of Illinois College of Medicine, Peoria, Illinois, United States

Klotho is a transmembrane protein expressed in the renal tubules and serves as an obligatory co-receptor for FGF23 to aid in phosphorus excretion. Prior studies have shown FGF23 resistance in SCD. The purpose of the study is to investigate urinary klotho/creatinine (Ur Kl/Cr) in pediatric SCD and no markers of ongoing renal damage ( eGFR > 90 ml/min and no microalbuminuria) and to compare it with healthy control population.


Cross sectional observational study to compare Ur Kl/Cr in pediatric SCD and controls. To do a sub group analysis among the study population to assess the effect of hydroxyurea(HU) on Ur Kl/Cr


20 control and 22 pediatric SCD were enrolled. In SCD group,13 were on HU. The baseline characteristic of the study and control group were same. Wilcoxon rank-sum test was used to compare the levels of Ur Kl/Cr ratio between SCD and control. For P value of 0.05, the levels of Ur Kl/Cr were statistically significantly higher in the sickle cell group (752.7 ± 1101.0) over the control group (216.8 ± 225.3). Subgroup analysis in the SCD group showed high Urinary Kl excretion in the non HU group(1346.7 ± 1523.4) vs non HU group (341.4 ± 355.3) but not statistically significant.(Fig 1 & 2)


Children with SCD tend to have increased secretion of Ur Kl/Cr compared to control likely due to tubular receptor resistance. HU tends to reverse this phenomenon by it's effect on preventing tubular damage.