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Kidney Week

Abstract: SA-OR113

Association of Reproductive Lifespan Duration and CKD in Postmenopausal Women

Session Information

Category: Women’s Health and Kidney Diseases

  • 2000 Women’s Health and Kidney Diseases

Authors

  • Kang, Shinchan, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Kim, Seonghun, Yonsei University, Seoul, Korea (the Republic of)
  • Ko, Byounghwi, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Jo, Wonji, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Nam, Yooju, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
  • Park, Jung Tak, Yonsei University College of Medicine, Seoul, Korea (the Republic of)
Background

Although animal studies have suggested estrogen to offer renoprotective effects, clinical evidence remains scarce. This study sought to investigate the relationship between endogenous estrogen exposure and renal function. Considering female reproductive lifespan duration (RLD) to be a surrogate of lifetime exposure to endogenous estrogen, the association of RLD and chronic kidney disease (CKD) was analyzed in postmenopausal women.

Methods

Data were retrieved from the Korean Genome and Epidemiology Study_Health Examinees cohort. A total of 57,505 postmenopausal women were included in the analysis. The RLD for each participant was determined by subtracting the age at menarche from the age at menopause. The participants were divided into groups according to RLD quartile. The association between RLD and CKD, defined as an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73m2, was examined.

Results

The mean age and eGFR of the study subjects were 57.7 ± 6.1 years and 88.0 ± 16.7 mL/min/1.73m2, respectively. The mean RLD was 34.2 ± 4.1 years. A total of 1,664 (2.89%) women were found to have CKD. The prevalence of CKD tended to decrease in groups with longer RLDs. Logistic regression analysis revealed that the odds ratio for CKD was lower in groups with longer RLDs as compared to the shortest RLD group. This finding was significant even following adjustments for confounding factors.

Conclusion

The prevalence of CKD was significantly lower in subjects with longer RLDs. The amount of endogenous estrogen exposure could be a determining factor for renal function in postmenopausal women.